Document Detail

Wound-healing effect of micronized sacchachitin (mSC) nanogel on corneal epithelium.
MedLine Citation:
PMID:  22956870     Owner:  NLM     Status:  MEDLINE    
The extraction residue of the Ganoderma fruiting body, named sacchachitin, has been demonstrated to have the potential to enhance cutaneous wound healing by inducing cell proliferation. In this study, a nanogel formed from micronized sacchachitin (mSC) was investigated for the potential treatment of superficial chemical corneal burns. Reportedly, mSC has been produced successfully and its chemical properties confirmed, and physical and rheological properties characterized. An in vitro cell proliferation study has revealed that at the concentrations of 200, 300, and 400 microg/mL, mSC nanogel significantly increased Statens Seruminstitut rabbit corneal (SIRC) cell proliferation after 24 hours of incubation. In cell migration assay, migration of SIRC cell to wound closure was observed after 24 hours of incubation with the addition of 200 microg/mL mSC of nanogel. In an animal study, acceleration of corneal wound healing was probably due to the inhibition of proteolysis. In conclusion, the findings of this study substantiate the potential application of sacchachitin in the form of mSC nanogel for the treatment of superficial corneal injuries.
Ray-Neng Chen; Lin-Wen Lee; Ling-Chun Chen; Hsiu-O Ho; Shiao-Chuan Lui; Ming-Thau Sheu; Ching-Hua Su
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-28
Journal Detail:
Title:  International journal of nanomedicine     Volume:  7     ISSN:  1178-2013     ISO Abbreviation:  Int J Nanomedicine     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-01-17     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101263847     Medline TA:  Int J Nanomedicine     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  4697-706     Citation Subset:  IM    
Department of Cosmetic Science and Management, Mackay Medicine, Nursing and Management College, Taipei, Republic of China.
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MeSH Terms
Burns, Chemical / drug therapy*,  physiopathology
Cell Movement / drug effects
Cells, Cultured
Drugs, Chinese Herbal / therapeutic use*
Epithelium, Corneal / drug effects,  injuries*,  metabolism*
Eye Burns / drug therapy*,  physiopathology
Gels / therapeutic use
Matrix Metalloproteinase 9 / metabolism*
Nanostructures / therapeutic use
Treatment Outcome
Wound Healing / drug effects,  physiology*
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Gels; 0/lingzhi; EC Metalloproteinase 9

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