Document Detail

Wound fluid lactate concentration: a helpful marker for diagnosing soft-tissue infection in diabetic foot ulcers? Preliminary findings.
MedLine Citation:
PMID:  21219425     Owner:  NLM     Status:  In-Process    
AIMS: To investigate the impact of wound fluid lactate concentration on diagnosing soft-tissue infection in diabetic foot ulcers.
METHODS: Lactate concentration in wound fluid obtained from diabetic foot ulcers was determined using a lactate analyser and compared with clinical examination findings.
RESULTS: Overall median wound fluid lactate concentration was 21.03 mm (5.58-80.40 mm). Wound lactate levels were significantly higher in infected compared with non-infected diabetic foot ulcers (P=0.001). Non-infected diabetic foot ulcers that healed within 6 months of treatment showed a significantly lower wound fluid lactate concentration at baseline as opposed to those that did not heal (P=0.007).
CONCLUSIONS: Non-healing diabetic foot ulcers are characterized by high wound fluid lactate levels. Assessment of wound fluid lactate concentration might be helpful for confirming the suspicion of soft tissue infection, particularly when clinical signs are atypical.
M Löffler; D Zieker; J Weinreich; S Löb; I Königsrainer; S Symons; S Bühler; A Königsrainer; H Northoff; S Beckert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  28     ISSN:  1464-5491     ISO Abbreviation:  Diabet. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK.
Department of General, Visceral and Transplant Surgery, Institute of Clinical and Experimental Transfusion Medicine, University of Tübingen, Hoppe-Seyler-Strasse 3, Tübingen, Germany.
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