| Wound-associated skin fibrosis: mechanisms and treatments based on modulating the inflammatory response. | |
| | |
MedLine Citation:
|
PMID: 20923404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Skin fibrosis, in its mildest form, may present only a minor aesthetic problem, but in the most severe cases it can lead to debilitating pathologies of the skin, for example keloid and hypertrophic scars, and systemic sclerosis. In recent years, extensive basic research aimed at understanding the molecular mechanisms underlying fibrosis has revealed an impressive but baffling number of genes, molecules, and cell types that may contribute to this problem. However, one recurring and consistent theme in these studies is that inflammatory cells and their secreted mediators appear to be leading culprits in activating dermal fibroblasts to become fibrotic. This review will first describe the histology of normal versus fibrotic skin, and will also describe the process of wound repair, a primary cause of skin fibrosis. We will then focus on what is currently known about the molecular mechanisms underlying skin fibrosis, with particular attention paid to how inflammation contributes. Finally, current treatment strategies and emerging therapeutic targets will be discussed. |
| | |
Authors:
|
Tanya J Shaw; Kazuo Kishi; Ryoichi Mori |
Related Documents
:
|
2162724 - Atopic dermatitis: a defect of intracellular secondary messenger systems? 2006874 - Cutaneous cellulitis. 8713004 - Pathological twists in association with infectious agents and infestations of the skin. 15797314 - Stress exposure modulates peptidergic innervation and degranulates mast cells in murine... 15962214 - Phagocytosis of salmonella montevideo by human neutrophils: immune adherence increases ... 11515814 - Nitric oxide and t helper cell immunity. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Endocrine, metabolic & immune disorders drug targets Volume: 10 ISSN: 2212-3873 ISO Abbreviation: Endocr Metab Immune Disord Drug Targets Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: 2011-04-18 Revised Date: 2012-04-19 |
Medline Journal Info:
|
Nlm Unique ID: 101269157 Medline TA: Endocr Metab Immune Disord Drug Targets Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 320-30 Citation Subset: IM |
Affiliation:
|
St George's, University of London, UK. tshaw@sgul.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cicatrix / genetics, immunology, pathology*, prevention & control Fibroblasts / immunology, pathology Fibrosis Humans Inflammation Mediators / metabolism* Signal Transduction* / genetics Skin / immunology, pathology* Wound Healing* / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The leptin system: a potential target for sepsis induced immune suppression.
Next Document: Molecular and vascular targets in the pathogenesis and management of the hypertension associated wit...