| Would wider screening for primary aldosteronism give any health benefits? | |
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MedLine Citation:
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PMID: 15362958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty years ago, Jerome Conn described 'a new clinical syndrome which is designated temporarily as primary aldosteronism' in a young patient with hypertension, severe hypokalaemia and a benign adrenocortical tumour, for whom an adrenalectomy cured both the hypertension and hypokalaemia. His report identified the condition known as aldosterone-producing adenoma, a form of curable hypertension. According to Conn, the prevalence of primary aldosteronism in the hypertensive population referred to his department was 20%, but this estimate was subject to referral bias. Primary aldosteronism has long been considered rare, with an estimated prevalence of 0.5-2% among unselected hypertensive patients. During the past 10 years, however, the apparent prevalence of the condition increased dramatically, up to 30% in some series. Overall, the prevalence of primary aldosteronism in series dealing with at least 100 screened hypertensive patients averaged 6%, with one patient in two harbouring an aldosterone-producing adenoma. This increase in prevalence reflects the fact that hypokalaemic and normokalaemic patients are now screened for primary aldosteronism, with the aldosterone to renin ratio used as a screening tool. The current 'epidemic' of primary aldosteronism raises several questions and concerns. |
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Authors:
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Pierre-Francois Plouin; Xavier Jeunemaitre |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 151 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-14 Completed Date: 2004-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 305-8 Citation Subset: IM |
Affiliation:
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Hypertension Unit, Hopital Europeen Georges Pompidou, Paris, France. pierre-francois.plouin@egp.ap-hop.paris.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Hyperaldosteronism / diagnosis*, epidemiology* Mass Screening* Prevalence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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