Document Detail

Would a morphomolecular approach help in defining pseudosarcomatous myofibroblastic proliferations? A study of a heart polypoid lesion.
MedLine Citation:
PMID:  19052027     Owner:  NLM     Status:  MEDLINE    
Many cardiac neoplasms lack pathognomonic clinical features, and this leads to controversial interpretations. As genomic changes may correlate with these malignancies and possibly aid in diagnosis, fluorescence in situ hybridisation (FISH) was used to study a polypoid lesion found incidentally at autopsy on the septal wall of the left ventricle of a 75-year-old man who had died from a heart attack. Histology and immunohistochemistry disclosed atypical stromal cells with irregular voluminous nuclei positive for vimentin and smooth muscle actin; these cells were reminiscent of those previously reported in a subset of nasal polyps showing aneuploidy. The scarce lymphoplasmocytic infiltrate hindering the diagnosis of inflammatory myofibroblastic tumours (IMT), and the presence of atypical cells, prompted the use of FISH: lack of ALK gene rearrangement and aneuploidy were observed in the irregular nuclei, supporting the diagnosis of a pseudosarcomatous myofibroblastic proliferation (PMP). These results stress that IMT and PMP may represent variants within a spectrum of myofibroblastic proliferations/tumours.
S Nemolato; T Dettori; P Caria; D V Frau; G Faa; R Vanni
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-03
Journal Detail:
Title:  Journal of clinical pathology     Volume:  62     ISSN:  1472-4146     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-9     Citation Subset:  AIM; IM    
Dipartimento di Citomorfologia, Università di Cagliari, Monserrato, Italy.
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MeSH Terms
Cell Proliferation
Chromosome Aberrations
Granuloma, Plasma Cell / diagnosis*,  genetics
Heart Neoplasms / diagnosis*,  genetics
Heart Septum
In Situ Hybridization, Fluorescence
Incidental Findings
Myofibroma / diagnosis*,  genetics
Polyps / diagnosis,  genetics
Comment In:
J Clin Pathol. 2009 Apr;62(4):289   [PMID:  19098061 ]

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