| Wortmannin interferes with thrombin-evoked secondary calcium redistribution in human platelets. | |
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MedLine Citation:
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PMID: 9419815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wortmannin has previously been reported to inhibit calcium entry in thrombin-stimulated human platelets. We extend these findings by demonstrating that the redistribution of calcium from intracellular stores features two separate, consecutive phases the second of which is selectively abolished by wortmannin. The primary release of calcium from Ins 1,4,5 P3-sensitive stores remains unaffected. Hence, wortmannin is interfering with regulation of any secondary, sustained calcium accumulation in the cytosolic compartment of activated platelets, originating either from intracellular stores or from calcium entry. We assume that wortmannin blocks a common step in receptor-dependent regulation of calcium entry. We assume that wortmannin blocks a common step in receptor-dependent regulation of calcium entry and intracellular calcium circulation. |
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Authors:
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F von Appen; V Ullrich; B Brüne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cellular signalling Volume: 9 ISSN: 0898-6568 ISO Abbreviation: Cell. Signal. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-19 Completed Date: 1998-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904683 Medline TA: Cell Signal Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 513-7 Citation Subset: IM |
Affiliation:
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University of Konstanz Faculty of Biology, Department of Biological Chemistry, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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pharmacology Androstadienes / pharmacology* Blood Platelets / cytology, drug effects*, physiology Calcium / metabolism* Enzyme Inhibitors / pharmacology* Humans Receptors, Thromboxane / agonists Second Messenger Systems / physiology* Signal Transduction Thrombin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Enzyme Inhibitors; 0/Receptors, Thromboxane; 19545-26-7/wortmannin; 7440-70-2/Calcium; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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