Document Detail

Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid.
MedLine Citation:
PMID:  9125129     Owner:  NLM     Status:  MEDLINE    
P19 EC cells undergoes apoptosis during neuronal differentiation induced by retinoic acid. Two CPP32-like proteases, CPP32 and Mch-3, are expressed in untreated and retinoic acid-treated P19 EC cells. CPP32-like activity is remarkably increased in apoptosis during neuronal differentiation of P19 EC cells. Inhibition of CPP32-like proteases prevents apoptosis, suggesting that activation of CPP32-like proteases play central roles in the apoptosis during neuronal differentiation of P19 EC cells. Wortmannin, PI-3K inhibitor, enhances the CPP32-like activity of the retinoic acid-treated P19 EC cells. PI-3K may be involved in the apoptosis during neuronal differentiation as negative regulator.
T Mukasa; Y Khoroku; T Tsukahara; M Y Momoi; I Kimura; T Momoi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  232     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-22     Completed Date:  1997-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/D86352;  D86353
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MeSH Terms
Androstadienes / pharmacology*
Carcinoma, Embryonal / pathology
Caspase 3
Cell Differentiation / drug effects*
Cysteine Endopeptidases / metabolism*
DNA Fragmentation
Molecular Sequence Data
Neurons / cytology,  drug effects*
Tretinoin / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Androstadienes; 19545-26-7/wortmannin; 302-79-4/Tretinoin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases; EC 3.4.22.-/Cysteine Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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