| Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid. | |
MedLine Citation:
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PMID: 9125129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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P19 EC cells undergoes apoptosis during neuronal differentiation induced by retinoic acid. Two CPP32-like proteases, CPP32 and Mch-3, are expressed in untreated and retinoic acid-treated P19 EC cells. CPP32-like activity is remarkably increased in apoptosis during neuronal differentiation of P19 EC cells. Inhibition of CPP32-like proteases prevents apoptosis, suggesting that activation of CPP32-like proteases play central roles in the apoptosis during neuronal differentiation of P19 EC cells. Wortmannin, PI-3K inhibitor, enhances the CPP32-like activity of the retinoic acid-treated P19 EC cells. PI-3K may be involved in the apoptosis during neuronal differentiation as negative regulator. |
Authors:
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T Mukasa; Y Khoroku; T Tsukahara; M Y Momoi; I Kimura; T Momoi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 232 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-04-22 Completed Date: 1997-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 192-7 Citation Subset: IM |
Affiliation:
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Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Tokyo, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/D86352; D86353 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androstadienes
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pharmacology* Apoptosis Carcinoma, Embryonal / pathology Caspase 3 Caspases* Cell Differentiation / drug effects* Cysteine Endopeptidases / metabolism* DNA Fragmentation Molecular Sequence Data Neurons / cytology, drug effects* Tretinoin / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 19545-26-7/wortmannin; 302-79-4/Tretinoin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases; EC 3.4.22.-/Cysteine Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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