Document Detail


Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid.
MedLine Citation:
PMID:  9125129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
P19 EC cells undergoes apoptosis during neuronal differentiation induced by retinoic acid. Two CPP32-like proteases, CPP32 and Mch-3, are expressed in untreated and retinoic acid-treated P19 EC cells. CPP32-like activity is remarkably increased in apoptosis during neuronal differentiation of P19 EC cells. Inhibition of CPP32-like proteases prevents apoptosis, suggesting that activation of CPP32-like proteases play central roles in the apoptosis during neuronal differentiation of P19 EC cells. Wortmannin, PI-3K inhibitor, enhances the CPP32-like activity of the retinoic acid-treated P19 EC cells. PI-3K may be involved in the apoptosis during neuronal differentiation as negative regulator.
Authors:
T Mukasa; Y Khoroku; T Tsukahara; M Y Momoi; I Kimura; T Momoi
Related Documents :
16825799 - Nerve growth factor, neural stem cells and alzheimer's disease.
17603039 - Cell systems and the toxic mechanism(s) of alpha-synuclein.
15599609 - Inflammatory process as a determinant factor for the degeneration of substantia nigra d...
10566959 - Differential actions of neurotrophins on apoptosis mediated by the low affinity neurotr...
15605989 - Ischemia leads to apoptosis--and necrosis-like neuron death in the ischemic rat hippoca...
15178829 - D-jnki1, a cell-penetrating c-jun-n-terminal kinase inhibitor, protects against cell de...
24749069 - Epidermal growth factor treatment of the adult brain subventricular zone leads to focal...
7885729 - The regulation of malaria parasitaemia: parameter estimates for a population model.
11149129 - Molecular basis of renal fibrosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  232     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-22     Completed Date:  1997-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Affiliation:
Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/D86352;  D86353
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Androstadienes / pharmacology*
Apoptosis
Carcinoma, Embryonal / pathology
Caspase 3
Caspases*
Cell Differentiation / drug effects*
Cysteine Endopeptidases / metabolism*
DNA Fragmentation
Molecular Sequence Data
Neurons / cytology,  drug effects*
Tretinoin / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Androstadienes; 19545-26-7/wortmannin; 302-79-4/Tretinoin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases; EC 3.4.22.-/Cysteine Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Suppression of L-histidine decarboxylase mRNA expression by methyleugenol.
Next Document:  Molecular cloning and expression of cDNAs encoding rat brain and liver cytosolic long-chain acyl-CoA...