| Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significance. | |
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MedLine Citation:
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PMID: 18279773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Renal function is a powerful prognostic variable in patients with heart failure (HF). Hospitalisations for acute HF (AHF) may be associated with further worsening of renal function (WRF). METHODS AND RESULTS: We analysed the clinical significance of WRF in 318 consecutive patients admitted at our institute for AHF. WRF was defined as the occurrence, at any time during the hospitalisation, of both a > or =25% and a > or =0.3 mg/dL increase in serum creatinine (s-Cr) from admission (WRF-Abs-%). RESULTS: Patients were followed for 480+/-363 days. Fifty-three patients (17%) died and 132 (41%) were rehospitalised for HF. WRF-Abs-% occurred in 107 (34%) patients. At multivariable survival analysis, WRF-Abs-% was an independent predictor of death or HF rehospitalisation (adjusted HR, 1.47; 95%CI, 1.13-1.81; p=0.024). The independent predictors of WRF-Abs-%, evaluated using multivariable logistic regression, were history of chronic kidney disease (p=0.002), LV ejection fraction (p=0.012), furosemide daily dose (p=0.03) and NYHA class (p=0.05) on admission. CONCLUSION: WRF is a frequent finding in patients hospitalised for AHF and is associated with a poor prognosis. Severity of HF and daily furosemide dose are the most important predictors of the occurrence of WRF. |
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Authors:
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Marco Metra; Savina Nodari; Giovanni Parrinello; Tania Bordonali; Silvia Bugatti; Rossella Danesi; Benedetta Fontanella; Carlo Lombardi; Patrizia Milani; Giulia Verzura; Gadi Cotter; Howard Dittrich; Barry M Massie; Livio Dei Cas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 10 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-05-28 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 188-95 Citation Subset: IM |
Affiliation:
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Section on Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia, Italy. metramarco@libero.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Creatinine / blood Diuretics / administration & dosage Female Furosemide / administration & dosage Heart Failure / mortality, physiopathology* Hospitalization Humans Kidney / physiopathology* Male Middle Aged Prognosis Prospective Studies Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 54-31-9/Furosemide; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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