| Worsening of hypoxemia with nitric oxide inhalation during bronchospasm in humans. | |
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MedLine Citation:
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PMID: 9696287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In some COPD patients, in contrast to those with ARDS, inhaled NO reportedly worsens hypoxemia. The issue examined in this study was whether inhaled NO improves or worsens hypoxemia in humans during bronchoconstriction induced by methacholine (MCh) nebulization. Five healthy subjects and six asthma patients were recruited, and during 80 ppm NO inhalation gas exchange parameters 10 min after MCh nebulization were compared with the values obtained while breathing NO-free air. During NO inhalation, the drop in PaO2 10 min after MCh, from 95.1 +/- 5.5 (baseline; mean +/- SD) to 68.9 +/- 6.2 Torr, was greater than that under the same conditions but breathing NO-free air (from 92.6 +/- 5.3 to 79.5 +/- 11.1 Torr), and the increase in AaDO2 (from 8.9 +/- 5.4 to 29.8 +/- 5.4 Torr) was greater than that during NO-free air breathing (from 8.5 +/- 7.6 to 15.4 +/- 9.2 Torr). The SaO2 dose-response reached a plateau at 5 ppm of NO. Our results show that NO inhalation worsens desaturation during bronchospasm in humans after MCh nebulization. |
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Authors:
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Y Takahashi; H Kobayashi; N Tanaka; K Honda; T Kawakami; T Tomita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiration physiology Volume: 112 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-10-13 Completed Date: 1998-10-13 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 113-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, School of Medicine, Kitasato University, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Anoxia / complications, physiopathology* Asthma / complications, physiopathology Dose-Response Relationship, Drug Female Humans Lung Diseases, Obstructive / complications, physiopathology Male Methacholine Chloride Middle Aged Nitric Oxide / adverse effects* Pulmonary Gas Exchange |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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