Document Detail

Worsening of hypoxemia with nitric oxide inhalation during bronchospasm in humans.
MedLine Citation:
PMID:  9696287     Owner:  NLM     Status:  MEDLINE    
In some COPD patients, in contrast to those with ARDS, inhaled NO reportedly worsens hypoxemia. The issue examined in this study was whether inhaled NO improves or worsens hypoxemia in humans during bronchoconstriction induced by methacholine (MCh) nebulization. Five healthy subjects and six asthma patients were recruited, and during 80 ppm NO inhalation gas exchange parameters 10 min after MCh nebulization were compared with the values obtained while breathing NO-free air. During NO inhalation, the drop in PaO2 10 min after MCh, from 95.1 +/- 5.5 (baseline; mean +/- SD) to 68.9 +/- 6.2 Torr, was greater than that under the same conditions but breathing NO-free air (from 92.6 +/- 5.3 to 79.5 +/- 11.1 Torr), and the increase in AaDO2 (from 8.9 +/- 5.4 to 29.8 +/- 5.4 Torr) was greater than that during NO-free air breathing (from 8.5 +/- 7.6 to 15.4 +/- 9.2 Torr). The SaO2 dose-response reached a plateau at 5 ppm of NO. Our results show that NO inhalation worsens desaturation during bronchospasm in humans after MCh nebulization.
Y Takahashi; H Kobayashi; N Tanaka; K Honda; T Kawakami; T Tomita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  112     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-10-13     Completed Date:  1998-10-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Department of Medicine, School of Medicine, Kitasato University, Kanagawa, Japan.
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MeSH Terms
Administration, Inhalation
Anoxia / complications,  physiopathology*
Asthma / complications,  physiopathology
Dose-Response Relationship, Drug
Lung Diseases, Obstructive / complications,  physiopathology
Methacholine Chloride
Middle Aged
Nitric Oxide / adverse effects*
Pulmonary Gas Exchange
Reg. No./Substance:
10102-43-9/Nitric Oxide; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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