Document Detail


Worming our way in and out of the Caenorhabditis elegans germline and developing embryo.
MedLine Citation:
PMID:  23331906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The germline and embryo of the nematode Caenorhabditis elegans have emerged as powerful model systems to study membrane dynamics in an intact, developing animal. In large part, this is due to the architecture of the reproductive system, which necessitates de novo membrane and organelle biogenesis within the stem cell niche to drive compartmentalization throughout the gonad syncytium. Additionally, membrane reorganization events during oocyte maturation and fertilization have been demonstrated to be highly stereotypic, facilitating the development of quantitative assays to measure the impact of perturbations on protein transport. This review will focus on regulatory mechanisms that govern protein trafficking, which have been elucidated using a combination of C. elegans genetics, biochemistry and high-resolution microscopy. Collectively, studies using the simple worm highlight an important niche that the organism holds to define new pathways that regulate vesicle transport, many of which appear to be absent in unicellular systems but remain highly conserved in mammals.
Authors:
Michael Hanna; Lei Wang; Anjon Audhya
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-02-06
Journal Detail:
Title:  Traffic (Copenhagen, Denmark)     Volume:  14     ISSN:  1600-0854     ISO Abbreviation:  Traffic     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-12-18     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  100939340     Medline TA:  Traffic     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-8     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Animals, Genetically Modified
Autophagy
Caenorhabditis elegans / embryology*
Cell Survival
Endocytosis
Gene Expression Regulation, Developmental*
Microscopy, Confocal
Oocytes / cytology
Protein Transport
Stem Cells / cytology*
Grant Support
ID/Acronym/Agency:
1R01GM088151/GM/NIGMS NIH HHS; R01 GM088151/GM/NIGMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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