Document Detail


World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries.
MedLine Citation:
PMID:  19432566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if vitamin C and E supplementation in high-risk pregnant women with low nutritional status reduces pre-eclampsia. DESIGN: Multicentred, randomised, controlled, double-blinded trial. SETTING: Antenatal care clinics and Hospitals in four countries. POPULATION: Pregnant women between 14 and 22 weeks' gestation. METHOD: Randomised women received 1000 mg vitamin C and 400 iu of vitamin E or placebo daily until delivery. MAIN OUTCOME MEASURES: Pre-eclampsia, low birthweight, small for gestational age and perinatal death. RESULTS: Six hundred and eighty-seven women were randomised to the vitamin group and 678 to the placebo group. Groups had similar gestational ages (18.1; SD 2.4 weeks), socio-economic, clinical and demographical characteristics and blood pressure at trial entry. Risk factors for eligibility were similar, except for multiple pregnancies: placebo group (14.7%), vitamins group (11.8%). Previous pre-eclampsia, or its complications, was the most common risk factor at entry (vitamins 41.6%, placebo 41.3%). Treatment compliance was 87% in the two groups and loss to follow-up was low (vitamins 2.0%, placebo 1.3%). Supplementation was not associated with a reduction of pre-eclampsia (RR: 1.0; 95% CI: 0.9-1.3), eclampsia (RR: 1.5; 95% CI: 0.3-8.9), gestational hypertension (RR: 1.2; 95% CI: 0.9-1.7), nor any other maternal outcome. Low birthweight (RR: 0.9; 95% CI: 0.8-1.1), small for gestational age (RR: 0.9; 95% CI: 0.8-1.1) and perinatal deaths (RR: 0.8; 95% CI: 0.6-1.2) were also unaffected. CONCLUSION: Vitamins C and E at the doses used did not prevent pre-eclampsia in these high-risk women.
Authors:
J Villar; M Purwar; M Merialdi; N Zavaleta; N Thi Nhu Ngoc; J Anthony; A De Greeff; L Poston; A Shennan;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  116     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-07-13     Revised Date:  2009-08-20    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  780-8     Citation Subset:  AIM; IM    
Affiliation:
Nuffield Department of Obstetrics and Gynaecology, Oxford Maternal and Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK. jose.villar@obs-gyn.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Ascorbic Acid / therapeutic use*
Developing Countries*
Dietary Supplements*
Double-Blind Method
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Small for Gestational Age
Nutritional Status
Pre-Eclampsia / prevention & control*
Pregnancy
Pregnancy Outcome
Prenatal Care / methods
Prenatal Nutritional Physiological Phenomena
Treatment Outcome
Vitamin E / therapeutic use*
Young Adult
Chemical
Reg. No./Substance:
1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid
Investigator
Investigator/Affiliation:
Peter Brockelhurst / ; André Van Asache / ; Douglas G Altman / ; Paul F A Van Look / ; M Purwar / ; C Doifode / ; S Fusey / ; C Sarodey / ; J Lalani / ; R Waghmare / ; S Zodpey / ; S Ughade / ; R Patil / ; P Attal / ; S Salve / ; S Mundle / ; N Zavaleta / ; M Huatuco / ; L Haro / ; T Enco / ; R Wong / ; S Chávez / ; S Ricco / ; T García / ; O Chumbe / ; K Espinoza / ; O Guzmán / ; I Ramírez / ; R Hinojosa / ; C Dávila / ; T Galarza / ; J Guerola / ; G Yucra / ; S Palian / ; L Gutierrez / ; N Cordero / ; L Chamberga / ; L Aguirre / ; N Casas / ; R Motta / ; L Untiveros / ; A Pinedo / ; P Cardoso / ; C Coveñas / ; S Ninaquispe / ; C Solano / ; R Ponce / ; H Vicuña / ; M Obeso / ; B Paredes / ; D Zuta / ; J Alva / ; J Huatuco / ; S Carcía / ; N T N Ngoc / ; N T Hieu / ; T Hanh Le / ; J Anthony / ; A de Greeff / ; A de Groot /
Comments/Corrections
Comment In:
BJOG. 2009 Sep;116(10):1416-7   [PMID:  19691635 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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