| 'Real world' comparison of drug-eluting stents vs bare metal stents in the treatment of unselected patients with acute ST-segment elevation myocardial infarction. | |
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MedLine Citation:
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PMID: 20453391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Concerns exist regarding the long-term efficacy and safety of drug-eluting stents (DES) in patients with ST-segment elevation myocardial infarction (STEMI). The study aimed to compare the mid- to long-term outcomes of DES vs bare metal stents (BMS) in patients with STEMI in a real-world setting. METHODS AND RESULTS: Six hundred and eighty four consecutive patients with STEMI who underwent percutaneous coronary intervention from January 2003 to December 2006 were analyzed; 539 patients (78.8%) with DES and 145 (21.2%) with BMS. Patients were followed for the occurrence of target vessel failure (TVF); a composite of cardiac death, non-fatal myocardial infarction, or target vessel revascularization (TVR). After a follow-up duration of 36 months, the TVF rate was significant lower in the DES group compared with the BMS group (17.8% vs 34.5%, P<0.01), which was mainly driven by a decrease in TVR (9.1% vs 22.8%, P<0.01). Diabetic patients, those with multivessel disease and those treated with smaller or longer stents benefited more from DES implantation. Propensity score matching concordantly indicated a benefit of DES with regard to TVF (13.5% vs 34.2%; P<0.01). The overall incidence of stent thrombosis (ST) in each group was comparable (3.9% vs 4.1%, P=0.47). CONCLUSIONS: Compared to BMS, the mid- to long-term outcome was better in patients receiving DES for acute STEMI. This was driven mainly by a reduction in repeat revascularization. |
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Authors:
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Kyung Woo Park; Si-Hyuck Kang; Woo-Young Chung; Hae-Young Lee; Jin-Shik Park; Hyun-Jae Kang; Young-Seok Cho; Tae-Jin Youn; Bon-Kwon Koo; In-Ho Chae; Dong-Ju Choi; Seokyung Hahn; Byung-Joo Park; Hyo-Soo Kim |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-20 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-07 Revised Date: 2011-02-18 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1111-20 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Drug-Eluting Stents / standards*, statistics & numerical data Female Follow-Up Studies Humans Longitudinal Studies Male Middle Aged Myocardial Infarction / therapy* Myocardial Revascularization Registries Retrospective Studies Stents / standards*, statistics & numerical data Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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