| Working women are better responders to beta-blocker monotherapy of mild hypertension than men. | |
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MedLine Citation:
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PMID: 15754917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this single-blind study was to compare the efficacy of betaxolol treatment (20 mg/day) on 24-h blood pressure profiles in working men and women with mild hypertension (grade 1 acc. ESH/ESC/JNC 2003), A group of 11 men and 11 women with a mean age 47+/-5 years underwent 24-h blood pressure monitoring after 8 days of placebo and after 20 days of treatment. A significant reduction (p < 0.05) in blood pressure was found for 11 h in men and 15 h in women (systolic) and 9 h in men and 13 h in women (diastolic). There was a tendency for a greater mean reduction in women (9.6/8.0 mmHg in men versus 12.9/7.4 mmHg in women). Diastolic blood pressure variability was significantly reduced in women (9.9 versus 13.1, respectively, p < 0.002) with a tendency for systolic blood pressure variability reduction (13.0 versus 15.1). The smoothness index for systolic blood pressure was higher in women (1.0/0.74 versus 0.64/0.61). A better response for betaxolol treatment 20 mg/day was observed in women in terms of target organ damage: a longer period of significant blood pressure reduction, lower variability and a tendency toward a greater reduction. |
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Authors:
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R Dabrowski; J Wozniak; I Kowalik; H Szwed |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 24 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 2004 |
Date Detail:
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Created Date: 2005-03-09 Completed Date: 2005-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Affiliation:
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II Ischemic Heart Disease Department, Institute of Cardiology, Warsaw, Poland. rafal.dabrowski@pf.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Betaxolol / therapeutic use* Female Humans Hypertension / drug therapy* Male Middle Aged Sex Factors Single-Blind Method Women, Working* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 63659-18-7/Betaxolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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