Document Detail

Working harder to stay alive: metabolic rate increases with age in Drosophila simulans but does not correlate with life span.
MedLine Citation:
PMID:  17915248     Owner:  NLM     Status:  MEDLINE    
The hypothesis that metabolic rate is inversely correlated with life span has long been debated. Another area of controversy has been the relationship between metabolic rate and aging. In most molecular studies key aspects of cellular metabolism have been shown to decline with age. Less attention has been focused on metabolic rate as an organism ages. We studied the survival of three Drosophila simulans fly lines and measured whole organism metabolic rate, mitochondrial DNA copy number and walking speed. Metabolic rate as assayed by CO(2) production did not correlate with median lifespan but increased by 0.43-1.14%/d. In contrast, mitochondrial DNA copy number decreased by 0.56-1.06%/d. Physical activity, as assayed by mean walking speed, did not change with age but was positively correlated with mitochondrial DNA copy number. One explanation for these data is that metabolic rate was increased, in the face of a reduced mitochondrial DNA copy number and capacity for oxidative metabolism, to maintain a constant bioenergetic demand (physical activity). Alternatively, metabolic rate may increase to provide energy for the repair of cellular damage or due to a shift in metabolic substrate use over time.
Richard G Melvin; Wayne A Van Voorhies; J William O Ballard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-07-22
Journal Detail:
Title:  Journal of insect physiology     Volume:  53     ISSN:  0022-1910     ISO Abbreviation:  J. Insect Physiol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-02     Completed Date:  2008-01-22     Revised Date:  2013-12-06    
Medline Journal Info:
Nlm Unique ID:  2985080R     Medline TA:  J Insect Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1300-6     Citation Subset:  IM    
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MeSH Terms
Aging / physiology*
Basal Metabolism
Drosophila / genetics,  metabolism*
Energy Metabolism / physiology*
Longevity / physiology
Oxygen Consumption
Grant Support
R01 GM 067862-01/GM/NIGMS NIH HHS; U56 CA 96286/CA/NCI NIH HHS; U56 CA096286/CA/NCI NIH HHS; U56 CA096286-05/CA/NCI NIH HHS

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