| Working capacity is increased following recombinant human erythropoietin treatment. | |
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MedLine Citation:
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PMID: 3199672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effect of partial correction of anemia in patients maintained by chronic intermittent hemodialysis on aerobic and anaerobic working capacity, eight patients underwent a bicycle spiro-ergometry before and after treatment with recombinant human erythropoietin (r-HuEPO). the initial mean (+/- SD) hemoglobin value was 5.9 mg/dl +/- 0.61 and increased during treatment to 10.9 +/- 0.59 mg/dl, P less than 0.0001). This partial correction of anemia resulted in a significant increase of both oxygen uptake at the anaerobic threshold and peak peripheral oxygen uptake at subjective exhaustion (P less than 0.01 and P less than 0.0002, respectively). The increase in oxygen uptake corresponded to significant increases in Watts, both at the anaerobic threshold and at maximum workload (P less than 0.02 and P less than 0.0004). These data show that partial correction of renal anemia results in a significant increase of both exercise capacity and maximum work. |
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Authors:
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G Mayer; J Thum; E M Cada; H K Stummvoll; H Graf |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Kidney international Volume: 34 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-01-25 Completed Date: 1989-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 525-8 Citation Subset: IM |
Affiliation:
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2nd Department of Medicine, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobiosis Anemia / physiopathology, therapy* Erythropoietin / therapeutic use* Female Humans Male Middle Aged Oxygen Consumption / drug effects Physical Exertion* Recombinant Proteins / therapeutic use Renal Dialysis |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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