Document Detail


Working memory ability predicts trajectories of early alcohol use in adolescents: the mediational role of impulsivity.
MedLine Citation:
PMID:  23033972     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: (i) To evaluate the role of pre-existing weakness in working memory ability (WM) as a risk factor for early alcohol use as mediated by different forms of impulsivity and (ii) to assess the adverse effects of progressive alcohol use on variations in WM over time.
DESIGN, SETTING AND PARTICIPANTS: A community sample of 358 adolescents [48% males, mean(age) (baseline) = 11.4 ± 0.87 years] from a longitudinal cohort design, assessed annually over 4 consecutive years with less than 6% attrition.
MEASUREMENTS: Repeated assessments were conducted for the following key variables: WM (based on performance on four separate tasks), frequency of alcohol use (AU) and three forms of impulsivity, namely sensation seeking (SS), acting without thinking (AWT) and delay discounting (DD). Latent growth curve modeling procedures were used to identify individual trajectories of change for all key variables.
FINDINGS: Weakness in WM (at baseline) predicted significantly both concurrent alcohol use and increased frequency of use over the four waves (P < 0.05). This effect was entirely mediated by two forms of impulsivity, AWT and DD, both of which were characterized by underlying weakness in WM. No individual variation was observed in the slopes of WM, which suggests that individual variations in alcohol use were not associated with changes in WM in our early adolescent sample.
CONCLUSIONS: Early adolescent alcohol use may be a consequence of (pre-existing) weaknesses in working memory (WM) rather than a cause of it. Efforts to reduce early alcohol use should consider the distinct roles of different impulsivity dimensions, in addition to WM, as potential targets of intervention.
Authors:
Atika Khurana; Dan Romer; Laura M Betancourt; Nancy L Brodsky; Joan M Giannetta; Hallam Hurt
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-01
Journal Detail:
Title:  Addiction (Abingdon, England)     Volume:  108     ISSN:  1360-0443     ISO Abbreviation:  Addiction     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-12-11     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  9304118     Medline TA:  Addiction     Country:  England    
Other Details:
Languages:  eng     Pagination:  506-15     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age of Onset
Alcohol Drinking / psychology*
Female
Humans
Impulsive Behavior / psychology*
Longitudinal Studies
Male
Memory, Short-Term / physiology*
Risk Factors
Grant Support
ID/Acronym/Agency:
R01 DA018913/DA/NIDA NIH HHS; R01 DA033996/DA/NIDA NIH HHS; R01DA018913/DA/NIDA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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