Document Detail


Working group consultation: alloimmunity as a vaccine approach against HIV/AIDS: National Institutes of Health Meeting Report, May 24, 2012.
MedLine Citation:
PMID:  23530996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alloimmunization vaccine strategies propose to avoid the problem of the extreme antigenic variability of human immunodeficiency virus (HIV) by instead focusing on the cellular antigens incorporated into HIV virions as they bud from infected cells. This report summarizes a Consultation meeting convened by the National Institute of Allergy and Infectious Diseases, National Institutes of Health on May 24, 2012. The objectives of the meeting were to (1) reach a consensus on the essential questions surrounding alloimmunization as a strategy for vaccine design against HIV, and (2) determine the experimental elements that might be needed for addressing these questions in an optimized pilot framework nonhuman primate (NHP) protocol for allogeneic immunization. The Consultation revisited the rationale and concerns of vaccination to induce allogeneic immunity, one of the most potent natural immune responses. The panelists' consensus was that a carefully designed skin graft transplant pilot experiment, in major histocompatibility complex (MHC) disparate male Mauritian cynomolgus macaques (MCM; Macaca fascicularis), would be useful for initially evaluating if alloimmunization results in an effective or even a partially effective safe AIDS vaccine. A successful NHP study for allogeneic immunization would provide further opportunities to explore vaccine-elicited immune and genetic correlates of protection against the acquisition of viral infection.
Authors:
Anjali Singh; Jon Warren; Alan Schultz; Charles J Hackett; Opendra Sharma
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Publication Detail:
Type:  Congresses; Research Support, N.I.H., Extramural     Date:  2013-04-23
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-08-30     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  851-8     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / immunology*
Animals
HIV / immunology*
HIV Infections / immunology,  prevention & control*
Humans
Isoantigens / immunology*,  therapeutic use
Macaca fascicularis / immunology
Macaca mulatta / immunology
Male
National Institutes of Health (U.S.)*
SAIDS Vaccines / immunology,  therapeutic use
Simian Acquired Immunodeficiency Syndrome / immunology,  prevention & control
Simian immunodeficiency virus / immunology
United States
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/Isoantigens; 0/SAIDS Vaccines
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