| Work in progress: in vitro analysis of pleural fluid analogs by proton magnetic resonance. Preliminary studies at 1.5T. | |
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MedLine Citation:
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PMID: 3597006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the potential of 1.5 Tesla magnetic resonance imaging (MRI) for assessing the protein concentration of pleural effusions, five pleural fluid analogs (saline + 0, 2, 4, 6, 8 g albumin/100 mL) and, for comparison, four saline dilutions of whole blood were evaluated in vitro. The relaxation rates (1/T1, 1/T2) of albumin solutions were determined by 1.5 T spectroscopy (MRS) and correlated with albumin concentration (1/T1:slope 0.02, r + 0.89, P less than .05; 1/T2: slope 0.16, r = 0.997, P less than .001). MRI studies of these solutions showed no significant correlation with 1/T1, but 1/T2 showed a positive correlation with albumin concentration (r = 0.98, P less than .01). Both MRI relaxation rates were significantly correlated with blood concentration, and slopes were greater than for albumin solutions. These preliminary studies, demonstrating differences in correlation between relaxation rates and the concentration of albumin and blood, suggest that MRI has the potential for differentiating pleural effusions of different chemical composition. |
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Authors:
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P Vock; L W Hedlund; R J Herfkens; E L Effmann; M A Brown; C E Putman |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 22 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-08-10 Completed Date: 1987-08-10 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 382-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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analysis Blood Humans Magnetic Resonance Spectroscopy / diagnostic use* Pleural Effusion / diagnosis* Spectrum Analysis |
| Chemical | |
Reg. No./Substance:
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0/Albumins |
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