Document Detail

Words in the brain's language.
MedLine Citation:
PMID:  11301524     Owner:  NLM     Status:  MEDLINE    
If the cortex is an associative memory, strongly connected cell assemblies will form when neurons in different cortical areas are frequently active at the same time. The cortical distributions of these assemblies must be a consequence of where in the cortex correlated neuronal activity occurred during learning. An assembly can be considered a functional unit exhibiting activity states such as full activation ("ignition") after appropriate sensory stimulation (possibly related to perception) and continuous reverberation of excitation within the assembly (a putative memory process). This has implications for cortical topographies and activity dynamics of cell assemblies forming during language acquisition, in particular for those representing words. Cortical topographies of assemblies should be related to aspects of the meaning of the words they represent, and physiological signs of cell assembly ignition should be followed by possible indicators of reverberation. The following postulates are discussed in detail: (1) assemblies representing phonological word forms are strongly lateralized and distributed over perisylvian cortices; (2) assemblies representing highly abstract words such as grammatical function words are also strongly lateralized and restricted to these perisylvian regions; (3) assemblies representing concrete content words include additional neurons in both hemispheres; (4) assemblies representing words referring to visual stimuli include neurons in visual cortices; and (5) assemblies representing words referring to actions include neurons in motor cortices. Two main sources of evidence are used to evaluate these proposals: (a) imaging studies focusing on localizing word processing in the brain, based on stimulus-triggered event-related potentials (ERPs), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI), and (b) studies of the temporal dynamics of fast activity changes in the brain, as revealed by high-frequency responses recorded in the electroencephalogram (EEG) and magnetoencephalogram (MEG). These data provide evidence for processing differences between words and matched meaningless pseudowords, and between word classes, such as concrete content and abstract function words, and words evoking visual or motor associations. There is evidence for early word class-specific spreading of neuronal activity and for equally specific high-frequency responses occurring later. These results support a neurobiological model of language in the Hebbian tradition. Competing large-scale neuronal theories of language are discussed in light of the data summarized. Neurobiological perspectives on the problem of serial order of words in syntactic strings are considered in closing.
F Pulvermüller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Behavioral and brain sciences     Volume:  22     ISSN:  0140-525X     ISO Abbreviation:  Behav Brain Sci     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2001-04-13     Completed Date:  2001-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808666     Medline TA:  Behav Brain Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  253-79; discussion 280-336     Citation Subset:  IM    
Department of Psychology, University of Konstanz, 78434 Konstanz, Germany.
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MeSH Terms
Association Learning / physiology*
Brain Mapping / methods*
Cerebral Cortex / metabolism,  physiology*,  radionuclide imaging
Cognition / physiology*
Dominance, Cerebral / physiology
Evoked Potentials
Magnetic Resonance Imaging
Memory / physiology*
Models, Neurological
Motor Cortex / physiology
Periaqueductal Gray / physiology
Tomography, Emission-Computed
Visual Cortex / physiology
Comment In:
Behav Brain Sci. 2004 Apr;27(2):307-8; discussion 308-11   [PMID:  15595243 ]

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