Document Detail

Women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes.
MedLine Citation:
PMID:  12196437     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This article tests the hypothesis that women with impaired glucose tolerance (IGT) have the same pregnancy outcomes as those of their counterparts with normal glucose tolerance. RESEARCH DESIGN AND METHODS: From December 1998 to December 1999, 84 of 90 antenatal care base units (ACBUs) under the Tianjin Antenatal Care Network in China participated in the first screening program for gestational diabetes mellitus (GDM). A total of 9,471 pregnant women under the care of participating ACBUs were screened. Of the women screened, 154 were positive for IGT. Of the 154 women, 102 opted for conventional obstetric care. The comparison group was 302 women of normal glucose tolerance (NGT). The initial screening consisted of a 50-g 1-h glucose test, and was carried out at 26-30 gestational weeks. Women with a serum glucose > or =7.8 mmol/l were followed up with a 75-g 2-h oral glucose tolerance test. The World Health Organization's diagnostic criteria for GDM were used. RESULTS: Women with IGT were at increased risk for premature rupture of membranes (P-ROM) (odds ratio [OR] 10.07; 95% CI 2.90-34.93); preterm birth (6.42; 1.46-28.34); breech presentation (3.47; 1.11-10.84); and high birth weight (90th percentile or 4,000 g) (2.42; 1.07-5.46); adjusting for maternal age, pregravid BMI, hospital levels, and other confounding factors. CONCLUSIONS: The presence of IGT in pregnancy is predictive of poor pregnancy outcomes.
Xilin Yang; Bridget Hsu-Hage; Hong Zhang; Cuiping Zhang; Yanni Zhang; Changjun Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes care     Volume:  25     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-28     Completed Date:  2003-02-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1619-24     Citation Subset:  IM    
Department of Rural Health, University of Melbourne, Melbourne, Australia. Tianjin Centre of Disease Control and Prevention, Tianjin, China. Tianjin Institute for Women's Health, Tianjin, China.
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MeSH Terms
Age Distribution
Diabetes Mellitus, Type 2 / epidemiology
Diabetes, Gestational / diagnosis,  epidemiology*
Glucose Intolerance / diagnosis,  epidemiology*
Hypertension, Renal / epidemiology
Predictive Value of Tests
Pregnancy Outcome / epidemiology*
Risk Factors

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