Document Detail

Women with high telomerase activity in luteinised granulosa cells have a higher pregnancy rate during in vitro fertilisation treatment.
MedLine Citation:
PMID:  21717175     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effect of telomerase activity (TA) in human luteinised granulosa cells (GCs) on the outcome of in vitro fertilisation treatment.
METHODS: Fifty-six women, aged 23 to 39 years, were enrolled and divided into four groups according to their levels of TA.
RESULTS: Seventeen cases in group A exhibited nondetectable TA, 16 cases in group B expressed low levels of TA (between 0.1 and 0.65 OD × mm), 14 cases in group C expressed moderate TA levels (between 0.66 and 1.00 OD × mm) and 9 cases in group D expressed high levels of TA (more than 1.00 OD × mm). The level of total serum testosterone (T) was significantly higher in groups C and D than in group A (1.43±0.10 vs. 1.08±0.11 nmol/L, P<0.030 and 1.56±0.08 vs. 1.08±0.11 nmol/L, P<0.005, respectively). The TA level was positively correlated with T (r=0.291, P<0.011). No obvious differences were observed in rates of fertilisation, cleavage, mature oocyte formation or good-quality embryos among the groups. The patients in group D exhibited the highest rates of embryo implantation and clinical pregnancy (with rates of 52.63% and 77.78%, respectively, compared with 18.92% and 29.41% in group A, 25.71% and 37.50% in group B and 48% and 50% in group C, with P<0.018 and P=0.112, respectively). The patients in group D also had a greater likelihood of becoming pregnant than those in group A (OR: 9.703, P < 0.023), group B (OR: 14.765, P<0.009) or group C (OR: 5.560, P=0.103).
CONCLUSIONS: Luteinised GCs have a certain potential for proliferation and TA of luteinised GCs may predict the clinical outcomes of IVF treatment. Some unknown regulatory mechanisms between TA and T should be studied in further trials.
Hong Chen; Wenjun Wang; Yaqin Mo; Yun Ma; Nengyong Ouyang; Ruiqi Li; Meiqi Mai; Yingming He; M M Abide Bodombossou-Djobo; Dongzi Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-30
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  28     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-09     Completed Date:  2012-01-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  797-807     Citation Subset:  IM    
Reproductive Medicine Centre, Department of Obstetrics and Gynaecology, Memorial Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
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MeSH Terms
Cell Proliferation
Embryo Transfer
Fertilization in Vitro*
Granulosa Cells / drug effects*,  enzymology
Ovulation Induction
Pregnancy Rate
Telomerase / metabolism*
Reg. No./Substance:

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