| Women with functional hypothalamic amenorrhea but not other forms of anovulation display amplified cortisol concentrations. | |
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MedLine Citation:
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PMID: 9176439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that increased cortisol secretion is specific to women with decreased GnRH drive and not found in eumenorrheic women or those with other causes of anovulation. DESIGN: Cortisol concentrations in blood were determined at 30-minute intervals for 24 hours in three well-characterized groups: women with functional hypothalamic amenorrhea, those with other causes of anovulation, and eumenorrheic women. SETTING: Academic medical center. PATIENT(S): Women aged 20 through 35 years, with well-defined reproductive states. INTERVENTION(S): Venous blood samples were obtained from, and psychometric inventories were completed by, the participants. MAIN OUTCOME MEASURE(S): Twenty-four-hour cortisol levels, 24-hour LH pulse patterns, and serial P levels were measured in women with functional hypothalamic amenorrhea, eumenorrheic women, and those with other causes of anovulation. RESULT(S): Cortisol secretion was higher in women with functional hypothalamic amenorrhea (n = 19) than in those with other causes of anovulation (n = 19) or eumenorrheic women (n = 19). Six women who recovered from functional hypothalamic amenorrhea had cortisol levels comparable to those of eumenorrheic women and those with other causes of anovulation. CONCLUSION(S): These data underscore the association between increased hypothalamic-pituitary-adrenal activity and reduced GnRH drive and support the concept that functional hypothalamic amenorrhea develops in response to stress-induced alterations in central neural function that modify hypothalamic function. |
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Authors:
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S L Berga; T L Daniels; D E Giles |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Fertility and sterility Volume: 67 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-06-26 Completed Date: 1997-06-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1024-30 Citation Subset: IM |
Affiliation:
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Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / blood* Anovulation / blood* Estradiol / blood Female Gonadotropin-Releasing Hormone / secretion* Humans Hydrocortisone / blood*, secretion Hypothalamus / physiopathology* Prolactin / blood Reference Values Stress, Physiological Thyrotropin / blood |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH/HD50748/MH/NIMH NIH HHS; RR-00056/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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