Document Detail


Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men.
MedLine Citation:
PMID:  20228684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Estrogen and progesterone improve neurologic outcomes in experimental models of cardiac arrest and stroke. Our objective was to determine whether women of child-bearing age are more likely than men to survive to hospital discharge after in-hospital cardiac arrest.
DESIGN: Prospective, observational study.
SETTING: Five hundred nineteen hospitals in the National Registry of Cardiopulmonary Resuscitation database.
PATIENTS: Patients included 95,852 men and women 15-44 yrs and 56 yrs or older with pulseless cardiac arrests from January 1, 2000 through July 31, 2008.
MEASUREMENTS AND MAIN RESULTS: Patients were stratified a priori by gender and age groups (15-44 yrs and > or =56 yrs). Fixed-effects regression conditioning on hospital was used to examine the relationship between age, gender, and survival outcomes. The unadjusted survival to discharge rate for younger women of child-bearing age (15-44 yrs) was 19% (940/4887) vs. 17% (1203/7025) for younger men (p = .013). The adjusted hospital discharge difference between these younger women and men was 2.8% (95% confidence interval, 1.0% to 4.6%; p = .002), and these younger women also had a 2.6% (95% confidence interval, 0.9% to 4.3%; p = .002) absolute increase in favorable neurologic outcome. For older women compared with men (> or =56 yrs), there were no demonstrable differences in discharge rates (18% vs. 18%; adjusted difference, -0.1%; 95% confidence interval, -0.9% to 0.6%; p = .68) or favorable neurologic outcome (14% vs. 14%; adjusted difference, -0.1%; 95% confidence interval, -0.7% to 0.5%; p = .74).
CONCLUSIONS: Women of child-bearing age were more likely than comparably aged men to survive to hospital discharge after in-hospital cardiac arrest, even after controlling for etiology of arrest and other important variables.
Authors:
Alexis A Topjian; A Russell Localio; Robert A Berg; Evaline A Alessandrini; Peter A Meaney; Paul E Pepe; G Luke Larkin; Mary Ann Peberdy; Lance B Becker; Vinay M Nadkarni;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  38     ISSN:  1530-0293     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-14     Revised Date:  2014-05-23    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1254-60     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Female
Heart Arrest / mortality*
Hospital Mortality
Humans
Male
Middle Aged
Prospective Studies
Sex Factors
Survival Rate
Young Adult
Grant Support
ID/Acronym/Agency:
K23 NS075363/NS/NINDS NIH HHS
Comments/Corrections
Comment In:
Crit Care Med. 2010 May;38(5):1378-9   [PMID:  20404631 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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