| Wolff-Parkinson-White syndrome and isolated left ventricular abnormal trabeculation as a manifestation of Leber's hereditary optic neuropathy. | |
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MedLine Citation:
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PMID: 11329546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial thickening and isolated left ventricular abnormal trabeculation (ILVAT) have not been described in patients with Leber's hereditary optic neuropathy (LHON) before. Wolff-Parkinson-White syndrome, myocardial thickening and ILVAT were found by electrocardiogram, echocardiography and cardiac magnetic resonance imaging in a 48-year-old man with bilateral, severely reduced visual acuity since age 24 years, palpitations since age 43 years and lower limb muscle cramps since age 47 years. Because ILVAT is frequently associated with respiratory chain disorders, neurological investigations were initiated, revealing the primary LHON mutation G3460A in lymphocytic mitochondrial DNA. On the basis of the clinical and genetic data, LHON was diagnosed in the index patient, but also in the patient's brother who showed ILVAT as well. Wolff-Parkinson-White syndrome, myocardial thickening and ILVAT may be rare manifestations of LHON. |
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Authors:
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J Finsterer; C Stöllberger; W Kopsa; M Jaksch |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 17 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-01 Completed Date: 2001-06-07 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: 464-6 Citation Subset: IM |
Affiliation:
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Ludwig Boltzmann Institute for Research in Epilepsy and Neuromuscular Disorders, Vienna, Austria. fij@2nr.nkr.magwien.gv.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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complications* Humans Male Middle Aged Optic Atrophies, Hereditary / complications*, genetics Wolff-Parkinson-White Syndrome / complications* |
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