Document Detail


Wolbachia superinfections and the expression of cytoplasmic incompatibility.
MedLine Citation:
PMID:  8587875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strains of Drosophila simulans from Riverside, California (DSR) and Hawaii (DSH) harbour distinct strains of the cytoplasmic incompatibility microorganism Wolbachia, resulting in the expression of bidirectional incompatibility when crossed. D. simulans lines carrying both of these (superinfected) Wolbachia strains were generated by the transfer of infected DSH cytoplasm into DSR embryos by microinjection. The superinfected flies were unidirectionally incompatible with both DSR and DSH individuals. As a result of this pattern, the superinfected state was observed to replace single infections in laboratory populations. The ability of the superinfection to spread was modulated by the production of singly infected offspring from superinfected mothers: strain segregation was observed under crowded larval rearing conditions. An inverse correlation between the penetrance of the cytoplasmic incompatibility phenotype and the degree of larval crowding was also observed. The findings have implications for the evolution of bidirectionally incompatible strains, and lead to the prediction that superinfections should be relatively common in field populations. Evidence for a natural superinfection in the mosquito Aedes albopictus is discussed. The results also have applied significance for the generation of insect lines capable of driving desirable genes into populations already infected with Wolbachia, thus allowing repeated opportunities for population replacement.
Authors:
S P Sinkins; H R Braig; S L O'Neill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  261     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-25     Completed Date:  1996-03-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  325-30     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Aedes / microbiology
Animals
Base Sequence
Cell Line
Crosses, Genetic
DNA, Bacterial / analysis
Drosophila / genetics*,  microbiology*
Female
Male
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
RNA, Ribosomal, 16S / genetics
Rickettsiaceae / genetics,  pathogenicity,  physiology*
Superinfection
Symbiosis
Grant Support
ID/Acronym/Agency:
AI28778/AI/NIAID NIH HHS; AI34355/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/RNA, Ribosomal, 16S

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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