| Wolbachia bacteria in filarial immunity and disease. | |
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MedLine Citation:
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PMID: 11472559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphatic filarial nematodes are infected with endosymbiotic Wolbachia bacteria. Lipopolysaccharide from these bacteria is the major activator of innate inflammatory responses induced directly by the parasite. Here, we propose a mechanism by which Wolbachia initiates acute inflammatory responses associated with death of parasites, leading to acute filarial lymphangitis and adverse reactions to antifilarial chemotherapy. We also speculate that repeated exposure to acute inflammatory responses and the chronic release of bacteria, results in damage to infected lymphatics and desensitization of the innate immune system. These events will result in an increased susceptibility to opportunistic infections, which cause acute dermatolymphangitis associated with lymphoedema and elephantiasis. The recognition of the contribution of endosymbiotic bacteria to filarial disease could be exploited for clinical intervention by the targeting of bacteria with antibiotics in an attempt to reduce the development of filarial pathology. |
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Authors:
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M J Taylor; H F Cross; L Ford; W H Makunde; G B Prasad; K Bilo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Parasite immunology Volume: 23 ISSN: 0141-9838 ISO Abbreviation: Parasite Immunol. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-26 Completed Date: 2001-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910948 Medline TA: Parasite Immunol Country: England |
Other Details:
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Languages: eng Pagination: 401-9 Citation Subset: IM |
Affiliation:
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Cellular Immunology Laboratory, Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, Liverpool, UK. mark.taylor@liv.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Bacterial / immunology Brugia malayi / immunology, microbiology* Cytokines / metabolism Elephantiasis, Filarial / drug therapy, immunology* Filaricides / adverse effects, therapeutic use Humans Leukocytes / immunology Lipopolysaccharides / immunology* Symbiosis Wolbachia / immunology*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Cytokines; 0/Filaricides; 0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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