| Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells. | |
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MedLine Citation:
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PMID: 22607321 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Plasmacytoid dendritic cells (pDCs) fulfil multiple roles in immunity, and can secrete large amounts of interferon (IFN)-α. However, the available evidence suggests that they may actually counteract efficient antitumour immunity. Thus in melanoma, pDCs are abundant, but they are anergic and deficient in IFN-α secretion. pDC anergy is thought to be caused by immunosuppressive factors secreted by melanoma cells. One factor strongly expressed by melanoma is Wnt5a, which is implicated in cancer tissue invasion. In this paper, we show that Wnt5a is able to block the upregulation of the activation markers CD80 and CD86 on naive human pDCs stimulated by CpG oligodeoxynucleotide, and CpG-triggered secretion of IFN-α by pDCs. Our results suggest that Wnt5a may not only initiate cancer invasion, but could also regulate activation of pDC. These data provide a clear rationale to investigate a role for Wnt5a in immune regulation. |
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Authors:
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K Hack; L Reilly; C Proby; C Fleming; I Leigh; J Foerster |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-21 |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: - ISSN: 1365-2230 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© The Author(s). CED © 2012 British Association of Dermatologists. |
Affiliation:
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Medical Research Institute, University of Dundee Medical School, Dundee, UK Cancer Research UK Cancer Centre Dundee, Dundee, UK NHS Tayside Department of Dermatology, Ninewells Hospital, Dundee, UK Education Division, College of Medicine Dentistry and Nursing, University of Dundee, Dundee, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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