| Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis. | |
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MedLine Citation:
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PMID: 19681164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epithelial tubes are crucial to the function of organ systems including the cardiovascular system, pulmonary system, gastrointestinal tract, reproductive organ systems, excretory system, and auditory system. Using a variety of animal model systems, recent studies have substantiated the role of Wnt signaling via the canonical/beta-catenin-mediated trajectory, the non-canonical Wnt trajectories, or both, in forming epithelial tubular tissues. This review focuses on the involvement of the Wnt pathways in the induction, specification, proliferation, and morphogenesis involved in tubulogenesis within tissues including the lungs, kidneys, ears, mammary glands, gut, and heart. The ultimate goal is to describe the developmental processes forming the various tubulogenic organ systems to determine the relationships between these processes. |
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Authors:
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Rachel K Miller; Pierre D McCrea |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-24 Completed Date: 2010-04-02 Revised Date: 2013-03-27 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 77-93 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. rkmiller@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Cardiovascular System / embryology Cell Polarity / physiology Ear, Inner / embryology Epithelium / embryology* Female Gastrointestinal Tract / embryology Gastrulation / physiology* Kidney Tubules / embryology Ligands Mammary Glands, Animal / embryology Models, Animal Models, Biological Morphogenesis* Neurulation / physiology* Respiratory System / embryology Signal Transduction / physiology* Wnt Proteins / metabolism* beta Catenin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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F32 DK082145/DK/NIDDK NIH HHS; F32 DK082145-02/DK/NIDDK NIH HHS; R01 GM052112/GM/NIGMS NIH HHS; R01 GM052112-15S1/GM/NIGMS NIH HHS; T32 HD007325-24/HD/NICHD NIH HHS; T32 HD07325/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Wnt Proteins; 0/beta Catenin; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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