| Wnt signaling in normal and malignant hematopoiesis. | |
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MedLine Citation:
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PMID: 23378582 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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One of the most remarkable characteristics of stem cells is their ability to perpetuate themselves through self-renewal while concomitantly generating differentiated cells. In the hematopoietic system, stem cells balance these mechanisms to maintain steady-state hematopoiesis for the lifetime of the organism, and to effectively regenerate the system following injury. Defects in the proper control of self-renewal and differentiation can be potentially devastating and contribute to the development of malignancies. In this review, we trace the emerging role of Wnt signaling as a critical regulator of distinct aspects of self-renewal and differentiation, its contribution to the maintenance of homeostasis and regeneration, and how the pathway can be hijacked to promote leukemia development. A better understanding of these processes could pave the way to enhancing recovery after injury and to developing better therapeutic approaches for hematologic malignancies. |
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Authors:
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William Lento; Kendra Congdon; Carlijn Voermans; Marcie Kritzik; Tannishtha Reya |
Publication Detail:
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Type: Journal Article Date: 2013-02-01 |
Journal Detail:
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Title: Cold Spring Harbor perspectives in biology Volume: 5 ISSN: 1943-0264 ISO Abbreviation: Cold Spring Harb Perspect Biol Publication Date: 2013 |
Date Detail:
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Created Date: 2013-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101513680 Medline TA: Cold Spring Harb Perspect Biol Country: United States |
Other Details:
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Languages: eng Pagination: - Citation Subset: IM |
Affiliation:
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Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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