Document Detail


Wnt signaling in normal and malignant hematopoiesis.
MedLine Citation:
PMID:  23378582     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
One of the most remarkable characteristics of stem cells is their ability to perpetuate themselves through self-renewal while concomitantly generating differentiated cells. In the hematopoietic system, stem cells balance these mechanisms to maintain steady-state hematopoiesis for the lifetime of the organism, and to effectively regenerate the system following injury. Defects in the proper control of self-renewal and differentiation can be potentially devastating and contribute to the development of malignancies. In this review, we trace the emerging role of Wnt signaling as a critical regulator of distinct aspects of self-renewal and differentiation, its contribution to the maintenance of homeostasis and regeneration, and how the pathway can be hijacked to promote leukemia development. A better understanding of these processes could pave the way to enhancing recovery after injury and to developing better therapeutic approaches for hematologic malignancies.
Authors:
William Lento; Kendra Congdon; Carlijn Voermans; Marcie Kritzik; Tannishtha Reya
Publication Detail:
Type:  Journal Article     Date:  2013-02-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  5     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Affiliation:
Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
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