Document Detail


Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans.
MedLine Citation:
PMID:  20624379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Wnt signaling pathway regulates multiple aspects of the development of stem cell-like epithelial seam cells in Caenorhabditis elegans, including cell fate specification and symmetric/asymmetric division. In this study, we demonstrate that lit-1, encoding the Nemo-like kinase in the Wnt/beta-catenin asymmetry pathway, plays a role in specifying temporal identities of seam cells. Loss of function of lit-1 suppresses defects in retarded heterochronic mutants and enhances defects in precocious heterochronic mutants. Overexpressing lit-1 causes heterochronic defects opposite to those in lit-1(lf) mutants. LIT-1 exhibits a periodic expression pattern in seam cells within each larval stage. The kinase activity of LIT-1 is essential for its role in the heterochronic pathway. lit-1 specifies the temporal fate of seam cells likely by modulating miRNA-mediated silencing of target heterochronic genes. We further show that loss of function of other components of Wnt signaling, including mom-4, wrm-1, apr-1, and pop-1, also causes heterochronic defects in sensitized genetic backgrounds. Our study reveals a novel function of Wnt signaling in controlling the timing of seam cell development in C. elegans.
Authors:
Haiyan Ren; Hong Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-17
Journal Detail:
Title:  Developmental biology     Volume:  345     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-55     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Graduate Program in Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / cytology,  growth & development*,  metabolism*
Caenorhabditis elegans Proteins / genetics,  metabolism
Cell Lineage
Cytoskeletal Proteins / genetics,  metabolism
DNA-Binding Proteins / genetics,  metabolism
Embryo, Nonmammalian / metabolism
Gene Silencing
High Mobility Group Proteins / genetics,  metabolism
Membrane Proteins / genetics,  metabolism
MicroRNAs / metabolism
Protein-Serine-Threonine Kinases / genetics,  metabolism
Ribonuclease III / genetics,  metabolism
Signal Transduction*
Stem Cells / cytology*
Wnt Proteins / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Cytoskeletal Proteins; 0/DNA-Binding Proteins; 0/High Mobility Group Proteins; 0/Membrane Proteins; 0/MicroRNAs; 0/WRM-1 protein, C elegans; 0/Wnt Proteins; 0/mom-4 protein, C elegans; 0/pop-1 protein, C elegans; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/lit-1 protein, C elegans; EC 3.1.26.-/dcr-1 protein, C elegans; EC 3.1.26.3/Ribonuclease III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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