Document Detail

Wnt signaling in vertebrate neural development and function.
MedLine Citation:
PMID:  23015196     Owner:  NLM     Status:  MEDLINE    
Members of the Wnt family of secreted signaling proteins influence many aspects of neural development and function. Wnts are required from neural induction and axis formation to axon guidance and synapse development, and even help modulate synapse activity. Wnt proteins activate a variety of downstream signaling pathways and can induce a similar variety of cellular responses, including gene transcription changes and cytoskeletal rearrangements. This review provides an introduction to Wnt signaling pathways and discusses current research on their roles in vertebrate neural development and function.
Kimberly A Mulligan; Benjamin N R Cheyette
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-27
Journal Detail:
Title:  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology     Volume:  7     ISSN:  1557-1904     ISO Abbreviation:  J Neuroimmune Pharmacol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-24     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101256586     Medline TA:  J Neuroimmune Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  774-87     Citation Subset:  IM    
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MeSH Terms
Axons / physiology
Brain / growth & development,  physiology
Cell Movement / physiology
Dendrites / physiology
Nervous System / growth & development*
Nervous System Physiological Phenomena
Neurogenesis / physiology
Synapses / physiology
Vertebrates / physiology*
Wnt Signaling Pathway / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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