Document Detail


TCF/LEFs and Wnt signaling in the nucleus.
MedLine Citation:
PMID:  23024173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are multifunctional proteins that use their sequence-specific DNA-binding and context-dependent interactions to specify which genes will be regulated by Wnts. Much of the work to define their actions has focused on their ability to repress target gene expression when Wnt signals are absent and to recruit β-catenin to target genes for activation when Wnts are present. Recent advances have highlighted how these on/off actions are regulated by Wnt signals and stabilized β-catenin. In contrast to invertebrates, which typically contain one TCF/LEF protein that can both activate and repress Wnt targets, gene duplication and isoform complexity of the family in vertebrates have led to specialization, in which individual TCF/LEF isoforms have distinct activities.
Authors:
Ken M Cadigan; Marian L Waterman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-11-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  4     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-04-15     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Cell Nucleus / physiology*
Evolution, Molecular*
Gene Components
Gene Expression Regulation / physiology*
Histones / metabolism
Models, Biological*
Molecular Sequence Data
Protein Structure, Tertiary
Species Specificity
TCF Transcription Factors / genetics*,  metabolism*
Wnt Signaling Pathway / physiology*
beta Catenin / metabolism
Grant Support
ID/Acronym/Agency:
CA096878/CA/NCI NIH HHS; CA108697/CA/NCI NIH HHS; GM082994/GM/NIGMS NIH HHS; P30 CA062203/CA/NCI NIH HHS; R01 CA096878/CA/NCI NIH HHS; R01 CA108697/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Histones; 0/TCF Transcription Factors; 0/beta Catenin
Comments/Corrections

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