| Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. | |
| | |
MedLine Citation:
|
PMID: 20205789 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Soluble amyloid-beta (Abeta;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Abeta oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Wnt signaling plays an important role in neural development, including synaptic differentiation. RESULTS: We report here that the Wnt signaling activation prevents the synaptic damage triggered by Abeta oligomers. Electrophysiological analysis of Schaffer collaterals-CA1 glutamatergic synaptic transmission in hippocampal slices indicates that Wnt-5a increases the amplitude of field excitatory postsynaptic potentials (fEPSP) and both AMPA and NMDA components of the excitatory postsynaptic currents (EPSCs), without modifying the paired pulse facilitation (PPF). Conversely, in the presence of Abeta oligomers the fEPSP and EPSCs amplitude decreased without modification of the PPF, while the postsynaptic scaffold protein (PSD-95) decreased as well. Co-perfusion of hippocampal slices with Wnt-5a and Abeta oligomers occludes against the synaptic depression of EPSCs as well as the reduction of PSD-95 clusters induced by Abeta oligomers in neuronal cultures. Taken together these results indicate that Wnt-5a and Abeta oligomers inversely modulate postsynaptic components. CONCLUSION: These results indicate that post-synaptic damage induced by Abeta oligomers in hippocampal neurons is prevented by non-canonical Wnt pathway activation. |
| | |
Authors:
|
Waldo Cerpa; Ginny G Farías; Juan A Godoy; Marco Fuenzalida; Christian Bonansco; Nibaldo C Inestrosa |
Related Documents
:
|
15269259 - Differences in hippocampal neuronal population responses to modifications of an environ... 6272929 - Changes in neuronal transmission in the rat hippocampus during behavior. 19666749 - Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhi... 23544409 - Navigated transcranial magnetic stimulation for mapping the motor cortex in patients wi... 21930349 - Immunohistochemical expression of proinflammatory cytokines il-1β, il-6, tnf-α and in... 10583499 - Synchronization of gabaergic interneuronal networks during seizure-like activity in the... 22986829 - Forebrain organization in elasmobranchs. 18524629 - Brain correlates of autonomic modulation: combining heart rate variability with fmri. 9292869 - Cell death in perinatal hypoxic-ischaemic brain injury. |
Publication Detail:
|
Type: Journal Article Date: 2010-01-18 |
Journal Detail:
|
Title: Molecular neurodegeneration Volume: 5 ISSN: 1750-1326 ISO Abbreviation: Mol Neurodegener Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-03-08 Completed Date: 2011-07-14 Revised Date: 2011-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 101266600 Medline TA: Mol Neurodegener Country: England |
Other Details:
|
Languages: eng Pagination: 3 Citation Subset: - |
Affiliation:
|
Centro de Envejecimiento y Regeneración (CARE), Centro de Regulación Celular y Patología "Joaquín V, Luco" (CRCP), MIFAB, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. ninestrosa@bio.puc.cl. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Haemoptysis in pregnancy caused by a well-differentiated fetal adenocarcinoma: a case report.
Next Document: Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interact...