| Within-woman change in regulatory T cells from pregnancy to the postpartum period. | |
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MedLine Citation:
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PMID: 20961621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regulatory T cells (Treg cells) are an important area of investigation in human health and disease. In this study, the trajectory of percentage of Treg cells (defined as CD4+CD25+Foxp3+CD127--lymphocytes) was measured in the blood of 208 women during pregnancy and up to three additional times in the postpartum period (1, 6 and 12 months postpartum). Whether the trajectory was affected by gravidity, parity, neonatal sex, pet exposure, maternal atopic and asthma status, smoking, maternal race or other pregnancy factors was examined. Multilevel models were fit using full maximum likelihood methods and included both random and fixed effects. Overall, percentages of Treg cells increased from the prenatal to the postpartum period. Among women who were not atopic, nulliparous women had lower percentages of Treg cells over time compared with parous women. Atopic women with pets in the home during pregnancy had lower percentages of Treg cells than atopic women who did not have pets. The trajectory was not affected by the other factors investigated. We conclude that within-woman change in percentages of Treg cells may vary by time in relation to delivery, as well as by maternal atopic status and exposure to pets and number of prior births. The data did not indicate an overall decline in Treg cells in the postpartum period. Future work to better identify the role of Treg cells in successful pregnancy would ideally include a set of well characterized women sampled serially starting prior to pregnancy and throughout the postpartum period. |
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Authors:
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Ganesa Wegienka; Suzanne Havstad; Kevin R Bobbitt; Kimberley J Woodcroft; Edward M Zoratti; Dennis R Ownby; Christine Cole Johnson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-18 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 88 ISSN: 1872-7603 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-21 Completed Date: 2011-06-28 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 58-65 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI 48202, USA. gwegien1@hfhs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD4
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genetics Asthma / immunology Continental Population Groups Female Flow Cytometry Fluorescent Antibody Technique Forkhead Transcription Factors / genetics Gravidity / immunology Humans Interleukin-2 Receptor alpha Subunit / genetics Interleukin-7 Receptor alpha Subunit / genetics, immunology Lymphocyte Count Parity / immunology Pets Postpartum Period / genetics, immunology* Pregnancy / immunology* Smoking / immunology T-Lymphocyte Subsets / immunology* T-Lymphocytes, Regulatory / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI069271/AI/NIAID NIH HHS; AI070606/AI/NIAID NIH HHS; K01 AI070606-01A2/AI/NIAID NIH HHS; K01 AI070606-02/AI/NIAID NIH HHS; K01 AI070606-03/AI/NIAID NIH HHS; K01 AI070606-04/AI/NIAID NIH HHS; R21 AI069271-01A1/AI/NIAID NIH HHS; R21 AI069271-02/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-2 Receptor alpha Subunit; 0/Interleukin-7 Receptor alpha Subunit |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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