Document Detail

Within and transgenerational immune priming in an insect to a DNA virus.
MedLine Citation:
PMID:  20861049     Owner:  NLM     Status:  MEDLINE    
Invertebrates mount a sophisticated immune response with the potential to exhibit a form of immune memory through 'priming'. Increased immune protection following early exposure to bacteria has been found both later in life (within generation priming) and in the next generation (transgeneration priming) in a number of invertebrates. However, it is unclear how general immune priming is and whether immune priming occurs in response to different parasites, including viruses. Here, using Plodia interpuctella (Lepidoptera) and its natural DNA virus, Plodia interpunctella granulosis virus, we find evidence for both within generation and transgeneration immune priming. Individuals previously exposed to low doses of virus, as well as the offspring of exposed individuals, are subsequently less susceptible to viral challenge. Relatively little is known about the mechanisms that underpin viral immunity but it is probable that the viral immune response is somewhat different to that of bacteria. We show that immune priming may, however, be a characteristic of both responses, mediated through different mechanisms, suggesting that immune memory may be a general phenomenon of insect immunity. This is important because immune priming may influence both host-parasite population and evolutionary dynamics.
Hannah J Tidbury; Amy B Pedersen; Mike Boots
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-22
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  278     ISSN:  1471-2954     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-09     Completed Date:  2011-06-23     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  871-6     Citation Subset:  IM    
Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK.
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MeSH Terms
Granulovirus / immunology*
Immunity, Innate
Immunologic Memory
Moths / immunology*,  virology

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