| Within-patient variation of hemoglobin and reticulocytes: implications for evaluating ESA responsiveness in dialysis patients. | |
| | |
MedLine Citation:
|
PMID: 22672348 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: Techniques that assess percent reticulocytes (%retics) or hemoglobin (Hb) to detect erythropoiesis-stimulating agents (ESA) use in athletes may be useful in evaluating ESA responsiveness in dialysis patients. However, within-patient variation, appropriate transformation, or the relationship between the blood draw interval length and analyte variation are untested. Methods: In a prospective, single-arm trial, we determined Hb and %retics in 30 hemodialysis patients receiving stable ESA doses. Within-patient results were evaluated for variance homogeneity and normality with and without transformation. Results: Square-root transformation (sqrt) of %retics produced the most constant variance (lowest r-value for correlation between sqrt|normalized residuals| and fitted values: 0.018 highest P-value 0.739) compared with log transformation (r = -0.198, P < 0.001) or no transformation (r = 0.215, P < 0.001) and showed the least departure from normality (highest P-value: 0.002 vs. < 0.001 vs. < 0.001, respectively). Hb results did not improve with transformation. Within-patient variance in both %retics and Hb increased with interval length between lab draws (P < 0.001). Conclusions: Initial assessment of anti-doping tool use in dialysis patient anemia management indicates square-root transformation of %retics and adjustment for time between lab draw intervals for both %retics and Hb will be required. |
| | |
Authors:
|
D B VAN Wyck; I Giles; K Sharpe |
Related Documents
:
|
2558938 - Interdigestive gastroduodenal motility in patients with active and inactive duodenal ul... 8189988 - Treatment of aphthous ulcers in aids patients. 16137998 - Perforated duodenal diverticulitis: a report of three cases. 9048868 - Bacterial colonization and healing of venous leg ulcers. 17433368 - The pattern of epileptic seizures in rural tanzania. 9110058 - Excretory urography before prostatectomy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-6 |
Journal Detail:
|
Title: International journal of laboratory hematology Volume: - ISSN: 1751-553X ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101300213 Medline TA: Int J Lab Hematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Blackwell Publishing Ltd. |
Affiliation:
|
DaVita Inc., Denver, CO, USA Sysmex, Mundelein, IL, USA University of Melbourne, Melbourne, Vic., Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development and validation of a real-time PCR assay for detection and quantification of Tuber magnat...
Next Document: Management and risk factors for mortality in very elderly patients with acute myocardial infarction.