Document Detail

Within-Visit Variability of Blood Pressure and All-Cause and Cardiovascular Mortality Among US Adults.
MedLine Citation:
PMID:  22372776     Owner:  NLM     Status:  In-Data-Review    
J Clin Hypertens (Greenwich). 2012;14:165-171. ©2012 Wiley Periodicals, Inc. The association between within-visit variability of systolic blood pressure (SBP) and diastolic blood pressure (DBP) and all-cause and cardiovascular (CVD) mortality was examined using the Third National Health and Nutrition Survey (n=15,317). Three SBP and DBP readings were taken by physicians during a single medical evaluation. Within-visit variability for each participant was defined using the standard deviation of SBP and DBP across these measurements. Mortality was assessed over 14 years (n=3848 and n=1684 deaths from all causes and CVD, respectively). After age, sex, and race-ethnicity adjustment, the hazard ratios (95% confidence intervals) for all-cause mortality associated with the 4 highest quintiles of within-visit standard deviation of SBP (2.00-2.99 mm Hg, 3.00-3.99 mm Hg, 4.00-5.29 mm Hg, and ≥5.30 mm Hg) compared with participants in the lowest quintile of within-visit standard deviation of SBP (<2.0 mm Hg) were 1.04 (0.87-1.26), 1.09 (0.92-1.29), 1.06 (0.88-1.28), and 1.13 (0.95-1.33), respectively (P=.136). The analogous hazard ratios for CVD mortality were 0.95 (0.69-1.32), 0.96 (0.67-1.36), 0.95 (0.74-1.23), and 1.04 (0.80-1.35), respectively (P=.566). No association with mortality was present after further adjustment and when modeling within-visit standard deviation of SBP as a continuous variable. Standard deviation of DBP was not associated with mortality.
Paul Muntner; Emily B Levitan; Kristi Reynolds; Devin M Mann; Marcello Tonelli; Suzanne Oparil; Daichi Shimbo
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Publication Detail:
Type:  Journal Article     Date:  2012-01-24
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  14     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
From the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL;Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA;Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University, Boston, MA;Department of Medicine, University of Alberta, Edmonton, AB;Department of Medicine, University of Alabama at Birmingham, Birmingham, AL;Department of Medicine, Columbia University, New York, NY.
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