Document Detail

Withholding clopidogrel for 3 to 6 versus 7 days or more before surgery in hip fracture patients.
MedLine Citation:
PMID:  24014772     Owner:  NLM     Status:  MEDLINE    
PURPOSE. To compare morbidity and mortality after hip fracture surgery in patients withholding clopidogrel for 3 to 6 days versus ≥7 days or more. METHODS. Records of 16 men and 31 women aged 49 to 92 (mean, 80.2) years who underwent hip fracture surgery after withholding clopidogrel for 3 to 6 days (n=24) versus ≥7 days or more (n=23) were compared. The patients were taking clopidogrel owing to ischaemic heart disease (n=37), cerebrovascular disease (n=7), and intolerance to aspirin (n=3). Patient demographics, American Society of Anesthesiologists status, preoperative delay, length of hospital stay, perioperative haemoglobin reduction, receipt of blood and platelet transfusions, morbidity, and mortality were recorded. RESULTS. Respectively in the early-surgery and delayed-surgery groups, the mean surgical delay was 4.2 and 8.0 days, the mean length of hospital stay was 21.1 and 28.7 days, the mean peri-operative haemoglobin reduction was 1.5 and 1.1 g/dl, the mean units of blood transfusion per patient was 0.8 and 0.7. No severe intra-operative bleeding or wound haematoma was encountered in either group. Two patients in each group died within one month, and 2 more in the delayed-surgery group died within 3 months. The main cause of death was cardiovascular. CONCLUSION. Withholding clopidogrel for <7 days before surgery conferred no increased risk in hip fracture patients.
Ammar Al Khudairy; O Al-Hadeedi; M K Sayana; R Galvin; John F Quinlan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of orthopaedic surgery (Hong Kong)     Volume:  21     ISSN:  1022-5536     ISO Abbreviation:  J Orthop Surg (Hong Kong)     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-09-09     Completed Date:  2014-04-21     Revised Date:  2014-10-08    
Medline Journal Info:
Nlm Unique ID:  9440382     Medline TA:  J Orthop Surg (Hong Kong)     Country:  China    
Other Details:
Languages:  eng     Pagination:  146-50     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Blood Loss, Surgical / prevention & control
Hemorrhage / chemically induced,  prevention & control*
Hip Fractures / surgery*
Middle Aged
Orthopedic Procedures / mortality*,  statistics & numerical data
Platelet Aggregation Inhibitors / adverse effects*
Ticlopidine / adverse effects,  analogs & derivatives*
Time Factors
Withholding Treatment
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; A74586SNO7/clopidogrel; OM90ZUW7M1/Ticlopidine
Comment In:
BJU Int. 2014 Sep;114(3):318-9   [PMID:  25156500 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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