| Withdrawal syndromes associated with antipsychotic drugs. | |
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MedLine Citation:
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PMID: 30287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Withdrawal symptoms frequently follow abrupt discontinuation of antipsychotic compounds. In addition to other somatic symptoms, withdrawal-emergent dyskinesias may be observed. "Covert dyskinesia" refers to a masked form of tardive dyskinesia that becomes clinically detectable only after antipsychotic drugs are withdrawn or their dosage is reduced. Withdrawal dyskinesia appears under similar circumstances but disappears spontaneously in 6 to 12 weeks. Cholinergic overactivity and changes in dopamine-acetylcholine balance in the basal ganglia may underlie these withdrawal syndromes. The principal value of the concept of covert dyskinesia is in the secondary and tertiary prevention of tardive dyskinesia through early discovery and treatment. |
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Authors:
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G Gardos; J O Cole; D Tarsy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of psychiatry Volume: 135 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1978-12-20 Completed Date: 1978-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1321-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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physiology Acute Disease Adult Antipsychotic Agents* / administration & dosage Basal Ganglia / physiopathology Child Dopamine / physiology Dose-Response Relationship, Drug Humans Movement Disorders / etiology*, physiopathology Parkinson Disease, Secondary / physiopathology Recurrence Schizophrenia / drug therapy Schizophrenic Psychology Substance Withdrawal Syndrome* / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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