Document Detail

Withdrawal-induced antihypertensive effect of vasopressin: role of the L-arginine/nitric oxide pathway.
MedLine Citation:
PMID:  9315348     Owner:  NLM     Status:  MEDLINE    
The role of the endothelium-derived relaxing factor (EDRF), nitric oxide (NO), in the withdrawal-induced antihypertensive phenomenon (WAP) of arginine vasopressin (AVP) was studied in conscious unrestrained rats implanted with femoral arterial catheters for the measurement of arterial blood pressure. Cessation of a 3-h intravenous infusion of AVP (20 was followed by a large and long-lasting fall in mean arterial blood pressure below preinfusion control values in spontaneously hypertensive rats (SHR; -47.5 +/- 6.4 mmHg; 1 mmHg = 133.3 Pa) but not in normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) control rats. Chronic treatment of normotensive SD rats with the NO synthesis inhibitor, N omega-nitro-L-arginine (L-NNA; 0.5 g.L-1 in drinking water for 2 weeks), resulted in sustained hypertension. Similar to the SHR model, a large fall in blood pressure (-37.8 +/- 7.7 mmHg) was observed in this model of hypertension following cessation of the AVP infusion. In SHR, inhibition of NO synthesis with L-NNA (0.05 g.L-1 in drinking water for 2 weeks) failed to attenuate the fall in blood pressure following withdrawal of AVP. Chronic treatment with the NO precursor, L-arginine (L-Arg; 1.25 g.L-1 in drinking water for 2 weeks), did not affect the amplitude or the time course of the WAP in SHR. The results indicate that the L-Arg/NO pathway is not essential to the expression of the WAP to AVP in the SHR.
R T Talom; J R McNeill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  75     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-11-05     Completed Date:  1997-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  812-7     Citation Subset:  IM    
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Arginine / pharmacology,  physiology*
Arginine Vasopressin / pharmacology*
Blood Pressure / drug effects,  physiology
Enzyme Inhibitors / pharmacology
Hypertension / drug therapy,  metabolism
Nitric Oxide / biosynthesis,  physiology*
Nitroarginine / pharmacology
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Substance Withdrawal Syndrome / etiology*,  metabolism*
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Enzyme Inhibitors; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 113-79-1/Arginine Vasopressin; 2149-70-4/Nitroarginine; 74-79-3/Arginine

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