Document Detail


Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats.
MedLine Citation:
PMID:  22854309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increased availability of highly palatable foods is a major contributing factor toward the development of compulsive eating in obesity and eating disorders. It has been proposed that compulsive eating may develop as a form of self-medication to alleviate the negative emotional state associated with withdrawal from highly palatable foods. This study was aimed at determining whether withdrawal from chronic, intermittent access to a highly palatable food was responsible for the emergence of depressive-like behavior. For this purpose, a group of male Wistar rats was provided a regular chow diet 7 days a week (Chow/Chow), whereas a second group of rats was provided chow for 5 days a week, followed by a 2-day access to a highly palatable sucrose diet (Chow/Palatable). Following 7 weeks of diet alternation, depressive-like behavior was assessed during withdrawal from the highly palatable diet and following renewed access to it, using the forced swim test, the sucrose consumption test, and the intracranial self-stimulation threshold procedure. It was found that Chow/Palatable rats withdrawn from the highly palatable diet showed increased immobility time in the forced swim test and decreased sucrose intake in the sucrose consumption test compared with the control Chow/Chow rats. Interestingly, the increased immobility in the forced swim test was abolished by renewing access to the highly palatable diet. No changes were observed in the intracranial self-stimulation threshold procedure. These results validate the hypothesis that withdrawal from highly palatable food is responsible for the emergence of depressive-like behavior, and they also show that compulsive eating relieves the withdrawal-induced negative emotional state.
Authors:
Attilio Iemolo; Marta Valenza; Lisa Tozier; Clifford M Knapp; Conan Kornetsky; Luca Steardo; Valentina Sabino; Pietro Cottone
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  23     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-17     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  593-602     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / diet therapy,  etiology,  psychology
Behavior, Animal
Compulsive Behavior* / psychology
Depression / diet therapy,  etiology*,  psychology
Diet* / adverse effects,  psychology
Dietary Sucrose / administration & dosage
Energy Intake
Feeding Behavior* / psychology
Food Preferences* / psychology
Male
Rats
Rats, Wistar
Reward
Self Stimulation
Sensory Thresholds
Time Factors
Grant Support
ID/Acronym/Agency:
AA016731/AA/NIAAA NIH HHS; DA023680/DA/NIDA NIH HHS; DA030425/DA/NIDA NIH HHS; MH091945/MH/NIMH NIH HHS; MH093650A1/MH/NIMH NIH HHS; R00 DA023680/DA/NIDA NIH HHS; R01 DA030425/DA/NIDA NIH HHS; R01 MH091945/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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