Document Detail

Withania somnifera prevents acquisition and expression of morphine-elicited conditioned place preference.
MedLine Citation:
PMID:  23455447     Owner:  NLM     Status:  Publisher    
Previous studies have reported that some of the central effects of morphine are counteracted by the administration of the methanolic extract of the root of Indian ginseng, Withania somnifera Dunal (WSE). The present study sought to determine whether WSE affects acquisition and expression of morphine-elicited conditioned place preference (CPP) in CD-1 mice. In CPP acquisition experiments, WSE (0, 25, 50, and 100 mg/kg) was administered, during conditioning, 30 min before morphine (10 mg/kg), whereas in expression experiments, WSE (0, 25, 50, and 100 mg/kg) was administered 30 min before the postconditioning test. The results demonstrate (i) that WSE was devoid of motivational properties; (ii) that WSE (100 mg/kg) was devoid of effects on spontaneous and morphine-stimulated motor activity and on spatial memory; and (iii) that WSE (50 and 100 mg/kg) significantly prevented the acquisition and expression of CPP. Further, to characterize the receptor(s) involved in these effects, we studied, by receptor-binding assay, the affinity of WSE for µ-opioid and γ-aminobutyric acid B receptors. These experiments revealed a higher affinity of WSE for γ-aminobutyric acid B than for µ-opioid receptors. Overall, these results point to WSE as an interesting alternative tool, worthy of further investigation, to study opiate addiction.
Stefania Ruiu; Rosanna Longoni; Liliana Spina; Alessandro Orrù; Filippo Cottiglia; Maria Collu; Sanjay Kasture; Elio Acquas
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Publication Detail:
Journal Detail:
Title:  Behavioural pharmacology     Volume:  24     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  133-143     Citation Subset:  -    
aInstitute of Translational Pharmacology, UOS of Cagliari, National Research Council, Scientific and Technological Park of Sardinia - Polaris, Pula bDepartment of Life and Environmental Sciences, Pharmaceutical, Pharmacological and Nutraceutical Sciences Section cDepartment of Life and Environmental Sciences, Drug Sciences Section dDepartment of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology eCentre of Excellence on Neurobiology of Addiction fNational Institute of Neuroscience, INN, University of Cagliari, Cagliari, Italy gSanjivani College of Pharmaceutical Education & Research, Kopargaon, India.
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