Document Detail


Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development.
MedLine Citation:
PMID:  18538759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While most cranial ganglia contain neurons of either neural crest or placodal origin, neurons of the trigeminal ganglion derive from both populations. The Wnt signaling pathway is known to be required for the development of neural crest cells and for trigeminal ganglion formation, however, migrating neural crest cells do not express any known Wnt ligands. Here we demonstrate that Wise, a Wnt modulator expressed in the surface ectoderm overlying the trigeminal ganglion, play a role in promoting the assembly of placodal and neural crest cells. When overexpressed in chick, Wise causes delamination of ectodermal cells and attracts migrating neural crest cells. Overexpression of Wise is thus sufficient to ectopically induce ganglion-like structures consisting of both origins. The function of Wise is likely synergized with Wnt6, expressed in an overlapping manner with Wise in the surface ectoderm. Electroporation of morpholino antisense oligonucleotides against Wise and Wnt6 causes decrease in the contact of neural crest cells with the delaminated placode-derived cells. In addition, targeted deletion of Wise in mouse causes phenotypes that can be explained by a decrease in the contribution of neural crest cells to the ophthalmic lobe of the trigeminal ganglion. These data suggest that Wise is able to function cell non-autonomously on neural crest cells and promote trigeminal ganglion formation.
Authors:
Yasuyo Shigetani; Sara Howard; Sonia Guidato; Kenryo Furushima; Takaya Abe; Nobue Itasaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-07
Journal Detail:
Title:  Developmental biology     Volume:  319     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-08-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-58     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Culture Techniques
Cell Movement
Chick Embryo
Choristoma / genetics*
Cranial Nerve Diseases*
DNA, Complementary / genetics
Head
Intercellular Signaling Peptides and Proteins / physiology*
Mice
Nerve Tissue Proteins / genetics*
Neural Crest / cytology,  physiology*
Oligonucleotides, Antisense
Trigeminal Ganglion*
Trigeminal Nerve / embryology*
Grant Support
ID/Acronym/Agency:
MC_U117560543//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/Intercellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/Oligonucleotides, Antisense

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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