| Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development. | |
| | |
MedLine Citation:
|
PMID: 18538759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
While most cranial ganglia contain neurons of either neural crest or placodal origin, neurons of the trigeminal ganglion derive from both populations. The Wnt signaling pathway is known to be required for the development of neural crest cells and for trigeminal ganglion formation, however, migrating neural crest cells do not express any known Wnt ligands. Here we demonstrate that Wise, a Wnt modulator expressed in the surface ectoderm overlying the trigeminal ganglion, play a role in promoting the assembly of placodal and neural crest cells. When overexpressed in chick, Wise causes delamination of ectodermal cells and attracts migrating neural crest cells. Overexpression of Wise is thus sufficient to ectopically induce ganglion-like structures consisting of both origins. The function of Wise is likely synergized with Wnt6, expressed in an overlapping manner with Wise in the surface ectoderm. Electroporation of morpholino antisense oligonucleotides against Wise and Wnt6 causes decrease in the contact of neural crest cells with the delaminated placode-derived cells. In addition, targeted deletion of Wise in mouse causes phenotypes that can be explained by a decrease in the contribution of neural crest cells to the ophthalmic lobe of the trigeminal ganglion. These data suggest that Wise is able to function cell non-autonomously on neural crest cells and promote trigeminal ganglion formation. |
| | |
Authors:
|
Yasuyo Shigetani; Sara Howard; Sonia Guidato; Kenryo Furushima; Takaya Abe; Nobue Itasaki |
Related Documents
:
|
3985379 - The distribution and spatial organization of the extracellular matrix encountered by me... 3197929 - Development of the central nervous system of the larva of the ascidian, ciona intestina... 9187079 - Analysis of neural crest cell migration in splotch mice using a neural crest-specific l... 2380119 - Deterioration of hearing function in mice with neural crest defect. 12185849 - Initiating and guiding migration: lessons from border cells. 19026759 - Establishment of long term cultures of neural stem cells from adult sea bass, dicentrar... 1722119 - Connexin32 gap junction channels in stably transfected cells: unitary conductance. 16234089 - Ependymal/subventricular zone cells migrate to the peri-infarct region and differentiat... 6607119 - Alteration of the chemotactic response of nih/3t3 cells to pdgf by growth factors, tran... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-07 |
Journal Detail:
|
Title: Developmental biology Volume: 319 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-08 Completed Date: 2008-08-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 346-58 Citation Subset: IM |
Affiliation:
|
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Culture Techniques Cell Movement Chick Embryo Choristoma / genetics* Cranial Nerve Diseases* DNA, Complementary / genetics Head Intercellular Signaling Peptides and Proteins / physiology* Mice Nerve Tissue Proteins / genetics* Neural Crest / cytology, physiology* Oligonucleotides, Antisense Trigeminal Ganglion* Trigeminal Nerve / embryology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Complementary; 0/Intercellular Signaling Peptides and Proteins; 0/Nerve Tissue Proteins; 0/Oligonucleotides, Antisense |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fibulin-1 is required for morphogenesis of neural crest-derived structures.
Next Document: Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptid...