| Wisconsin card sorting test and brain perfusion imaging in early dementia. | |
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MedLine Citation:
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PMID: 20068307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The presence of frontal or executive deficits in patients even at early stages of dementia is now widely recognized. We investigated the relationship between the scores of the Wisconsin card sorting test (WCST) and brain perfusion in patients with early dementia. METHODS: A total of 77 subjects participated in this study. They underwent the WCST and brain single photon emission computed tomography with 99mTc-ethylcisteinate dimer. We analyzed the data using a regional cerebral blood flow (rCBF) quantification software program, 3DSRT. RESULTS: The number of categories achieved (CA) scores of the WCST had a weakly positive correlation with regional cerebral blood flow in the bilateral precentral, bilateral callosomarginal, bilateral pericallosal, right thalamus, left central and left parietal segments. The number of perseverative errors of the Nelson type (PEN) scores had a weakly negative correlation with rCBF in the right thalamus. CONCLUSION: The results in this study suggest that CA scores mainly reflect the function of the precentral segments, especially the left side, and that PEN scores correlate with rCBF in the right thalamus. The results suggest that CA scores and PEN scores should be differentially estimated in the WCST. |
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Authors:
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Naoya Takeda; Seishi Terada; Shuhei Sato; Hajime Honda; Hidenori Yoshida; Yuki Kishimoto; Gosuke Kamata; Etsuko Oshima; Takeshi Ishihara; Shigetoshi Kuroda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 29 ISSN: 1421-9824 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Copyright Information:
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2010 S. Karger AG, Basel. |
Affiliation:
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Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / physiopathology, psychology, radionuclide imaging Cerebrovascular Circulation / physiology* Dementia / physiopathology*, psychology*, radionuclide imaging Education Executive Function / physiology* Female Humans Male Middle Aged Neuropsychological Tests* Psychiatric Status Rating Scales Regression Analysis Tomography, Emission-Computed, Single-Photon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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