Document Detail


Wireless oesophageal pH monitoring: Establishing values in a multiracial cohort of asymptomatic Asian subjects.
MedLine Citation:
PMID:  23287012     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Wireless oesophageal (Bravo) readings in healthy European and American subjects show varied results. Values in Asians remain unstudied. AIMS: We performed Bravo studies in healthy Asians to determine if values differed from previously published and identified reflux parameters to differentiate healthy volunteers from patients. METHODS: Fifty healthy volunteers were recruited between August 2009 and August 2011 to undergo 48h wireless pH monitoring. Bravo capsule was introduced transorally and placed 6cm above the squamocolumnar junction. Acid reflux parameters were compared against 41 patients previously evaluated for non-erosive reflux disease. RESULTS: Five volunteers were excluded. Capsule dislodgement occurred in four and three volunteers on study days 1 and 2 respectively. Forty and 37 volunteers (73% male, mean age 33.0±7.6 years) had interpretable readings at 24 and 48h, respectively. Percentage of time oesophageal pH<4 in 37 volunteers who completed 48h recordings was 1.6% (7.5%), 1.5% (6.3%) and 1.9% (5.8%) on days 1, 2 and overall study duration, respectively. CONCLUSION: Bravo readings in Asians differed from previously published. Percentage of time oesophageal pH<4 on day 2 and DeMeester score on day 2 (95th percentile 22.9) best discriminated healthy volunteers from patients.
Authors:
Daphne Ang; Ying Xu; Tiing Leong Ang; Ngai Moh Law; Choo Hean Poh; Eng Kiong Teo; Kwong Ming Fock
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  -     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Gastroenterology, Changi General Hospital, Singapore. Electronic address: ang_daphne@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Smad7 antisense oligonucleotide-based therapy for inflammatory bowel diseases.
Next Document:  Benefits of pulmonary rehabilitation in patients with COPD with normal exercise capacity.