| Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit. | |
| | |
MedLine Citation:
|
PMID: 19655250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Assessment of whole gut transit, by radio-opaque markers or scintigraphy, is used to evaluate patients with constipation for slow gastrointestinal transit. Wireless capsule motility, using the SmartPill GI monitoring system, samples and transmits intraluminal pH, pressure, and temperature data from a capsule at regular intervals as it traverses through the gastrointestinal tract; from these, gastric emptying and whole gastrointestinal tract transit can be assessed. The objective of this study was to compare the SmartPill with whole gut transit scintigraphy to determine whether the SmartPill system could serve as a test for measurement of whole gut motility and transit. METHODS: Ten healthy, asymptomatic subjects underwent simultaneous whole gut scintigraphy and SmartPill assessment of whole gut transit. RESULTS: All subjects completed the study per protocol and experienced natural passage of the pill. Capsule residence time in the stomach correlated very strongly with percent gastric retention of the Tc-99 radiolabel at 120 min (r = 0.95) and at 240 min (r = 0.73). Small bowel contraction-min(-1) measured by the SmartPill correlated with small bowel transit % (r = 0.69; P = 0.05) and with isotopic colonic geometric center at 24 h after ingestion (r = 0.70, P = 0.024). Capsule transit time correlated with scintigraphic assessment of whole gut transit. CONCLUSIONS: SmartPill capsule assessment of gastric emptying and whole gut transit compares favorably with that of scintigraphy. Wireless capsule motility shows promise as a useful diagnostic test to evaluate patients for GI transit disorders and to study the effect of prokinetic agents on GI transit. |
| | |
Authors:
|
Sabba Maqbool; Henry P Parkman; Frank K Friedenberg |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-05 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 54 ISSN: 1573-2568 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-03 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 2167-74 Citation Subset: AIM; IM |
Affiliation:
|
Gastroenterology Section, Department of Medicine, 8th Floor Parkinson Pavilion, Temple University School of Medicine, Philadelphia, PA 19140, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Capsule Endoscopy Colon / physiology Constipation / diagnosis Female Gastric Emptying / physiology Gastrointestinal Motility / physiology Gastrointestinal Tract / radionuclide imaging* Gastrointestinal Transit / physiology* Humans Intestine, Small / physiology Male Middle Aged Monitoring, Physiologic / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endoscopic Management of Foreign Bodies in the Upper Gastrointestinal Tract in South China: A Retros...
Next Document: R-rated movie viewing, growth in sensation seeking and alcohol initiation: reciprocal and moderation...