Document Detail

Wireless capsule endoscopy in pediatric patients: the first series from Japan.
MedLine Citation:
PMID:  20143103     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of our study was to determine the safety and usefulness of capsule endoscopy (CE) in pediatric patients. METHODS: We prospectively examined children (aged 10-18 years) with suspected small bowel disease and recorded capsule transit times, findings, and complications. RESULTS: We performed 19 CE examinations in 12 patients (median age 11.8 years; range 10-18 years). One of the two patients with obscure gastrointestinal bleeding (OGIB), a 14-year-old girl whose OGIB occurred after cord-blood transplantation due to leukemia, was diagnosed with thrombotic microangiopathy. Repeated CE allowed visualization of real-time mucosal changes, such as the improvement of ulcers and bleeding, and newly emerged lymphangiectasia, without causing the patient physical and mental stress. This information facilitated both subsequent evaluation of the clinical course and determination of the appropriate treatment strategy. In the second patient with chronic OGIB, a 10-year-old girl, the detection of severe ileal stenoses by capsule retention led to the diagnosis of non-specific multiple ulcers of the small intestine. After ileal resection, repeated CE detected the recurrence of multiple ulcers and enabled the optimal treatment strategy to be applied. CE confirmed small bowel involvement in a patient with unresponsive Crohn's disease (CD) and excluded CD in all five patients with suspected CD. Similarly, CE confirmed the absence of small bowel involvement in three of the four patients with recurrent abdominal pain, although one patient had nodular lymphoid hyperplasia. CONCLUSIONS: Based on our results, CE is a valuable tool in the differential diagnoses of small bowel diseases, and repeated examination can provide real-time information that will enable evaluation of the clinical course in pediatric patients.
Daisuke Tokuhara; Kenji Watanabe; Yoshiyuki Okano; Akio Tada; Kazumi Yamato; Takahiro Mochizuki; Junji Takaya; Tsunekazu Yamano; Tetsuo Arakawa
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Publication Detail:
Type:  Journal Article     Date:  2010-02-09
Journal Detail:
Title:  Journal of gastroenterology     Volume:  45     ISSN:  1435-5922     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  683-91     Citation Subset:  IM    
Department of Pediatrics, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka, 545-8585, Japan.
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MeSH Terms
Abdominal Pain / etiology
Capsule Endoscopy / adverse effects,  methods*
Gastrointestinal Hemorrhage / diagnosis,  etiology
Intestinal Diseases / diagnosis*,  pathology
Intestine, Small / pathology*
Prospective Studies
Time Factors

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