Document Detail


Winner of the Brazier Award. The dysmature EEG pattern in infants with bronchopulmonary dysplasia and its prognostic implications.
MedLine Citation:
PMID:  1697238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bronchopulmonary dysplasia (BPD) is a chronic lung disease which occurs in premature infants who require prolonged mechanical ventilation and supplemental oxygen support. Infants with severe BPD often have neurological sequelae or early mortality. We have observed a pattern of delay in the maturation of cerebral electrical activity of some infants who have more severe forms of BPD. This delayed electroencephalographic (EEG) maturation or 'dysmaturity' is best recognized when the conceptional age (CA) of the premature infant approaches term and is characterized by the presence of EEG activity which normally disappears in premature infants by 36-37 weeks CA. We studied 36 infants with BPD who had serial EEGs and at least 1 EEG between 37 and 42 weeks CA. Dysmature EEGs were found in 23 infants. Unfavorable outcomes were found in 83% (19/23) of these infants, including 22% (5/23) mortality, and 61% (14/23) abnormal or suspect neurological outcome. Thirteen infants had EEGs which lacked dysmature features. Of these infants, 62% (8/13) had normal neurological outcome, and 38% (5/13) had unfavorable outcome (1 death, 2 abnormal, and 2 suspect). In 2 of the 5 infants with unfavorable outcomes without dysmature EEGs, a suppression-burst pattern (known to be associated with neurological sequelae) was found. The presence of dysmature patterns in the near-term or term EEG was associated with significantly less favorable outcome (P = 0.01). Several other clinical factors which were associated with dysmature EEGs are also discussed.
Authors:
J S Hahn; B R Tharp
Related Documents :
25165178 - Sudden death due to subarachnoid haemorrhage in an infant with autosomal dominant polyc...
19917958 - Unexpected occurrence of xeroderma pigmentosum in an uncle and nephew.
10494478 - Long-term neurodevelopmental outcome of asphyxiated newborns.
22705018 - Altered placental development in pregnancies resulting in sudden infant death syndrome ...
15492358 - Association of breastfeeding with maternal control of infant feeding at age 1 year.
21372798 - A prospective study on neonatal mortality and its predictors in a rural area in burkina...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Electroencephalography and clinical neurophysiology     Volume:  76     ISSN:  0013-4694     ISO Abbreviation:  Electroencephalogr Clin Neurophysiol     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-04     Completed Date:  1990-10-04     Revised Date:  2008-09-09    
Medline Journal Info:
Nlm Unique ID:  0375035     Medline TA:  Electroencephalogr Clin Neurophysiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  106-13     Citation Subset:  IM    
Affiliation:
Department of Neurology, Stanford University Medical Center, CA 94305.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Bronchopulmonary Dysplasia / physiopathology*
Electroencephalography*
Gestational Age
Humans
Infant, Newborn
Prognosis
Grant Support
ID/Acronym/Agency:
NS07280/NS/NINDS NIH HHS; NS12151/NS/NINDS NIH HHS; RR-00081/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Significance of thromboxane A2 and prostaglandin I2 in acute necrotizing pancreatitis in rats.
Next Document:  REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of n...