Document Detail

Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing.
MedLine Citation:
PMID:  9630221     Owner:  NLM     Status:  MEDLINE    
In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen, emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities along the D/V axis at short and long range. Here, we show that high levels of a Wg receptor, Drosophila frizzled 2 (Dfz2), stabilize Wg, allowing it to reach cells far from its site of synthesis. Wg signaling represses Dfz2 expression, creating a gradient of decreasing Wg stability moving toward the D/V boundary. This repression of Dfz2 is crucial for the normal shape of Wg morphogen gradient as well as the response of cells to the Wg signal. In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation.
K M Cadigan; M P Fish; E J Rulifson; R Nusse
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cell     Volume:  93     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-06     Completed Date:  1998-07-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-77     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA.
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MeSH Terms
Biological Transport
Blotting, Western
Body Patterning
Cell Communication
Drosophila / embryology*
Drosophila Proteins*
Frizzled Receptors
Gene Expression Regulation*
Genes, Insect
In Situ Hybridization
Models, Biological
Proto-Oncogene Proteins / metabolism*
Receptors, Cell Surface / biosynthesis*,  genetics
Receptors, G-Protein-Coupled
Receptors, Neurotransmitter*
Tissue Distribution
Wing / embryology*
Wnt1 Protein
Reg. No./Substance:
0/Drosophila Proteins; 0/Frizzled Receptors; 0/Proto-Oncogene Proteins; 0/Receptors, Cell Surface; 0/Receptors, G-Protein-Coupled; 0/Receptors, Neurotransmitter; 0/Wnt1 Protein; 0/fz2 protein, Drosophila; 0/wg protein, Drosophila

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