Document Detail


Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.
MedLine Citation:
PMID:  7605629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We generated mice with a null mutation of the forebrain-restricted transcription factor BF-1 to examine its function in brain development. Heterozygous animals have an apparently normal phenotype. Homozygous null BF-1 mutants die at birth and have a dramatic reduction in the size of the cerebral hemispheres. The development of the ventral telencephalon is more severely affected than that of the dorsal telencephalon. Telencephalic neuroepithelial cells are specified in the BF-1 mutant, but their proliferation is reduced. Dorsal telencephalic neuroepithelial cells also differentiate prematurely, leading to early depletion of the progenitor population. These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation.
Authors:
S Xuan; C A Baptista; G Balas; W Tao; V C Soares; E Lai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  14     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-08-11     Completed Date:  1995-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1141-52     Citation Subset:  IM    
Affiliation:
Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Brain / anatomy & histology,  embryology*
Cell Differentiation
Cell Division / physiology
Cerebral Cortex / cytology,  embryology
DNA-Binding Proteins / genetics,  physiology*
Epithelial Cells
Epithelium / embryology
Forkhead Transcription Factors
Heterozygote
Homozygote
Mice
Mice, Mutant Strains
Molecular Sequence Data
Morphogenesis
Mutation
Nerve Tissue Proteins / genetics,  physiology*
Telencephalon / cytology,  embryology
Grant Support
ID/Acronym/Agency:
R01HD29584/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Forkhead Transcription Factors; 0/Foxd1 protein, mouse; 0/Nerve Tissue Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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